Effects of Blackberry-derived Polyphenols on Cardiovascular Risk in Adults

Launched by UNIVERSITY COLLEGE CORK · Jan 30, 2015

Keywords

ClinConnect Summary

Dietary factors play a significant role in the prevention and/or treatment of hypertension and significant efforts are being put in to the development of functional foods with antihypertensive activity. Blackberries and their intrinsic polyphenols, consumed as part of a healthy diet, may be of functional interest in both the treatment and prevention of hypertension and dyslipidaemia. The Cardio-Rubus study presents healthy adults with an opportunity to participate in a human nutrition study that will assist in identifying biological effects of blackberry-derived components establishing furt...

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Eligibility criteria

• Inclusion Criteria:
• • Adult Caucasian men and women (ratio men: women, 70:30)
• • Good general health
• • Systolic blood pressure: 130 - 149 mmHg
• • Body mass index (BMI): 25.0 - 35.0 kg/m2
• • Signed consent form
• Exclusion Criteria:
• • Current smokers
• • Diagnosed hypertension
• • History of cardiovascular events such as stroke, myocardial infarction or peripheral vascular disease
• • Diagnosed medical illness including diabetes mellitus (Types 1 \& 2), chronic kidney disease and gastro-intestinal diseases
• • Medications that may affect any of the study outcome measures: anti-hypertensive medications and lipid lowering therapies e.g. statins.
• • Suspected hypersensitivity or allergy to berries.
• • Intolerance for aspirin or salicylate acid.
• • Current consumption of nutraceuticals, botanical extracts or other polyphenol-rich supplements.