Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide

Launched by THE UNIVERSITY OF TEXAS MEDICAL BRANCH, GALVESTON · Sep 29, 2017

Keywords

ClinConnect Summary

This clinical trial is studying the use of a medication called hydrochlorothiazide (HCTZ) to help prevent high blood pressure problems after pregnancy, specifically for women who have had conditions like gestational hypertension or preeclampsia. These are conditions that can occur during pregnancy and can lead to serious health issues if not managed properly. The trial is currently looking for women aged 18 to 50 who have had these conditions at any point during their pregnancy, labor, or shortly after giving birth.

If you qualify and choose to participate, you will receive HCTZ to see if it helps reduce the risk of returning high blood pressure after delivery. It's important to know that if you are already on high blood pressure medication, have certain health conditions, or cannot follow up after pregnancy, you may not be able to participate. This trial aims to better understand how to manage these complications for new mothers, ultimately improving their health after childbirth.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Maternal age ≥ 18 years and \<50 years.
• • Diagnosis of gestational hypertension\* or preeclampsia\^ at any time during pregnancy, labor or postpartum.
• • defined as isolated systolic BP of 140 mm Hg or greater, a diastolic BP of 90 mm Hg or greater, or both) or \^ defines as new-onset hypertension plus new-onset proteinuria, or in the absence of proteinuria, preeclampsia is diagnosed as hypertension in association with thrombocytopenia (platelet count less than 100,000/microliter), impaired liver function (elevated blood levels of liver transaminases to twice the normal concentration), the new development of renal insufficiency (elevated serum creatinine greater than 1.1 mg/dL or a doubling of serum creatinine in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances.)
• Exclusion Criteria:
• • Subject requiring antihypertensive therapy at time of screening.
• • Planned discharge with oral anti-hypertensive medication.
• • Contraindication to hydrochlorothiazide (advanced renal failure or anuria, hypersensitivity to sulfonamides).
• • Subject not able to follow up postpartum.
• • Lactose intolerance.
• • Pre-gestational diabetes.