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Search / Trial NCT04502225

Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure

Launched by VANDERBILT UNIVERSITY MEDICAL CENTER · Aug 5, 2020

Trial Information

Current as of November 14, 2025

Recruiting

Keywords

ClinConnect Summary

This clinical trial is studying how raising the head of the bed can help people with a condition called autonomic failure, which often leads to high blood pressure when lying down, also known as supine hypertension. The researchers want to see if by elevating the head of the bed, they can reduce the amount of blood that returns to the heart, which may help lower blood pressure without the need for medications. This could provide a simple, non-drug solution for managing this issue.

To participate in the trial, you need to be between 18 and 85 years old and have autonomic failure with supine hypertension. The study is looking for both men and women of all races. However, certain people are not eligible, including those who are pregnant, medical students, or anyone with serious health issues like heart problems or a history of certain illnesses. If you decide to take part, you can expect to be involved in an investigation that could lead to new, effective ways to manage your blood pressure while lying down.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Patients with autonomic failure and with supine hypertension from all races
  • Males and females, between 18 to 85 years
  • Exclusion Criteria:
  • All medical students
  • Pregnant women
  • High-risk patients (for example: heart failure, symptomatic coronary artery disease, liver impairment, history of stroke or myocardial infarction)
  • History of serious allergies or asthma.

About Vanderbilt University Medical Center

Vanderbilt University Medical Center (VUMC) is a leading academic medical center located in Nashville, Tennessee, renowned for its commitment to advancing healthcare through innovative research and clinical excellence. As a prominent sponsor of clinical trials, VUMC integrates cutting-edge scientific inquiry with patient-centered care, supporting a diverse array of studies aimed at enhancing medical knowledge and improving treatment outcomes. With a robust infrastructure and a multidisciplinary team of experts, VUMC fosters collaboration across various fields, ensuring the highest standards of safety and ethical considerations in its research endeavors. Through its dedication to medical discovery and education, VUMC plays a pivotal role in shaping the future of medicine.

Locations

Nashville, Tennessee, United States

Patients applied

0 patients applied

Trial Officials

Italo Biaggioni, MD

Principal Investigator

Vanderbilt University Medical Center

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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