Utility of Single-dose Oral Antibiotic Prophylaxis in Prevention of Surgical Site Infection in Dermatologic Surgery

Launched by CARILION CLINIC · Oct 6, 2020

Keywords

ClinConnect Summary

This clinical trial is studying whether taking a single dose of an oral antibiotic before certain skin surgeries can help prevent infections at the surgery site. It involves patients who will be undergoing specific procedures such as skin flap or graft repairs on the nose or ear, or Mohs surgery on the lower leg. The trial is looking for participants aged 18 and older who are planning to have these types of surgeries at the Carilion Clinic in Roanoke, Virginia.

Participants will be randomly placed in one of two groups: one group will receive the antibiotic, while the other will receive a placebo (a pill that looks the same but has no active medication). After the surgery, participants will be monitored for up to 30 days to see if they develop any infections. This study is important because it could help doctors understand how to better prevent infections for patients undergoing these common skin procedures. If you are eligible and decide to participate, you will play a role in helping improve patient care for future surgeries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18 years of age or older
• • presenting to Carilion Clinic Dermatology and Mohs surgery in Roanoke, VA at Riverside 1
• • suspected to undergo a single-staged repair including a skin flap or graft on the nose
• • OR suspected to undergo single-staged repair including a skin graft or flap or wedge resection 1 on the ear
• • OR undergoing Mohs with closure or partial closure or surgical excision on the lower extremity below the knee
• Exclusion Criteria:
• • patients with intellectual or mental impairment affecting ability to give informed consent
• • use of any antibiotic (other than intervention) within 48 hours of the surgery suspected infection at time of surgery
• • inability to take cephalexin or clindamycin hydrochloride due to allergy or intolerance current inflammatory skin disease affecting the surgical site
• • Patients undergoing concurrent surgery to oral or nasal mucosa
• • Patients who have had a recent prosthetic joint surgery within two years and have been told they require antibiotic prophylaxis.
• • Patients who are currently pregnant, concerned they could be pregnant, actively trying to conceive, or missed last menstrual period that is not explainable by a birth control method.