Basal Plasma Lithium Levels and Suicidal Events

Launched by UNIVERSITY HOSPITAL, MONTPELLIER · Jun 3, 2022

Keywords

ClinConnect Summary

This clinical trial is studying the connection between levels of lithium in the body and the risk of suicidal behavior in people with major depressive disorder and bipolar disorder. Lithium is a medication often used to treat bipolar disorder and has shown promise in reducing suicidal thoughts and actions. The researchers want to see how natural variations in lithium levels, which can be influenced by diet and lifestyle, may affect mental health in individuals who are struggling with these conditions.

To participate in the study, individuals must be at least 18 years old and currently experiencing a major depressive episode. They should not have taken any lithium-based treatments in the past year. Those who have had suicidal thoughts or attempts in the last 12 months may also be eligible, while individuals who have not experienced such events will serve as a comparison group. Participants can expect to undergo assessments and contribute to important research that aims to improve our understanding of mental health and suicide prevention. It's important to note that certain individuals, such as those with specific mental health diagnoses or who are pregnant, may not be eligible for this trial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18 years old or over
• • Current major depressive episode according to the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) criteria
• • No lithium-based treatment over the last 12 months
• • For suicide attempters/ideations only : suicidal event over the last 12 months
• • For affective controls only : no suicidal event over the last 12 months
• Exclusion Criteria:
• • Lifetime diagnosis of schizoaffective disorder, schizophrenia or psychosis
• • Pregnancy or breastfeeding
• • Deprivation of freedom (by judicial or administrative decision)
• • Legal protection measure (guardianship or curators)
• • Inability to understand experimental procedures
• • No affiliation to the French National Social Security System
• • No consent to participate in the study