Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study

Launched by MONASH UNIVERSITY · Jul 5, 2022

Keywords

ClinConnect Summary

The Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study is a clinical trial that aims to find out how long patients undergoing cardiac surgery should receive antibiotic treatment to prevent infections. Researchers will compare three different groups: one group will get antibiotics only during surgery, another group will receive them for 24 hours after surgery, and the last group will receive them for 48 hours after surgery. The goal is to see which duration is most effective at preventing surgical site infections and other related infections.

To participate in this study, you need to be an adult patient scheduled for cardiac surgery that involves a specific type of chest opening called a median sternotomy. Some people may not be eligible, including those under 18 years old or those with certain health conditions, like severe kidney issues or a history of serious infections. If you choose to join the trial, you will receive either the antibiotic or a placebo (a substance with no active medication) without knowing which one you have, helping to ensure fair results. Your involvement will contribute to important knowledge about infection prevention in cardiac surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • - Adult patients undergoing cardiac surgery involving a median sternotomy
• Exclusion Criteria:
• • Age \<18 years
• • American Society of Anesthesiology (ASA) 5
• • Subjects with GFR \<40mL/min/1.73m2 or those requiring continuous renal replacement therapy, haemodialysis or peritoneal dialysis
• • Surgery for suspected or proven endocarditis or deep sternal wound infection
• • Documented cefazolin hypersensitivity
• • Documented methicillin resistant Staphylococcus aureus (MRSA) colonisation or infection in the 12-months prior to index surgery
• • Cardiac transplantation
• • Procedures involving insertion ventricular assist device or mechanical circulatory support device
• • Procedures not involving a median sternotomy
• • Patients previously enrolled and randomised to the CALIPSO trial