INtestinal Dysbiosis and TRanslocation of Bacteria in Patients Undergoing Surgery

Launched by INSEL GRUPPE AG, UNIVERSITY HOSPITAL BERN · Mar 7, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how changes in gut bacteria may affect patients who are having surgery. Specifically, it aims to find out if surgery can cause a temporary imbalance in the gut's normal bacteria (called dysbiosis) and whether this imbalance can lead to infections at the surgery site. The researchers will collect various samples and health information from patients undergoing certain types of elective abdominal surgeries, like colorectal resection or duodeno-pancreatectomy, to better understand these relationships.

To be eligible for the study, participants must be at least 18 years old and scheduled for one of the targeted surgeries. Those who have had recent surgeries, are undergoing emergency surgery, or have certain health conditions (like severe liver or kidney disease) will not be included. If you join the study, you can expect to provide health information and samples before, during, and after your surgery. The goal is to help improve patient care and reduce the risk of infections after surgery.

Gender

ALL

Eligibility criteria

• Inclusion criteria:
• • Patients undergoing laparoscopic colorectal resection with anastomosis or patients undergoing duodeno-pancreatectomy.
• • Elective surgery
• • Informed consent
• • Age \> 18 years
• Exclusion criteria:
• • Emergency surgery
• • Other surgery 30 days prior to colorectal surgery
• • BMI \<18 or \>50kg/m2
• • Planed simultaneous second procedure with involvement of the intestinal tract
• • Cholestasis with cholangitis, hepatic disease (defined as cirrhosis Child B or C) or renal disease (acute or chronic renal failure defined as eGFR≤ 30ml/min)
• • Severe active enteritis or colitis, malabsorption, enteric infections
• • Pancreatitis