Comparison of a Morphomic-Based to the Standard-of-Care-Based Cefazolin Dose for Antimicrobial Prophylaxis

Launched by UNIVERSITY OF MICHIGAN · Aug 16, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how to best dose an antibiotic called cefazolin for overweight patients who are having surgery. The main goal is to find out if using a person's body composition (like the amount of fat and muscle) instead of just their body weight can lead to better antibiotic levels in their blood and fat tissue. This is important because having the right amount of antibiotic is crucial for preventing infections after surgery. During the trial, participants will have small amounts of blood and fat tissue collected while they are undergoing their routine surgery.

To be eligible for this trial, participants need to be adults over 18 years old with a Body Mass Index (BMI) of 25 or higher, indicating they are overweight. They must also have had a CT scan of their abdomen before surgery and are expected to receive cefazolin before their surgery begins. Unfortunately, individuals with a history of allergies to certain antibiotics or those who are pregnant cannot participate. If you join the study, you can help researchers learn how to improve antibiotic use for patients like you and potentially reduce the risk of infections after surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Accessible abdominal computed tomography scan prior to surgery
• • 2. Adult patients \> 18 years of age
• • 3. Body Mass Index ≥ 25 kg/m\^2
• • 4. Expected to receive cefazolin prior to surgical incision
• • 5. Estimated creatinine clearance ≥90 mL/min
• Exclusion Criteria:
• • 1. History of a hypersensitivity reaction to penicillin or cephalosporin
• • 2. Pregnancy