Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen

Launched by SERVIER BIO-INNOVATION LLC · Nov 7, 2023

Keywords

ClinConnect Summary

This clinical trial, called the CHONQUER study, is examining the effectiveness of a medication called ivosidenib for patients with a specific type of cancer known as conventional chondrosarcoma that has either spread to other parts of the body or cannot be removed by surgery. To participate, individuals must have a confirmed diagnosis of chondrosarcoma with an IDH1 mutation, and they should have had either no previous treatment or just one prior treatment for their cancer. The trial is looking for participants who have measurable disease progression, meaning their cancer has grown or returned after treatment.

If eligible, participants will be randomly assigned to receive either ivosidenib or a placebo (a non-active treatment) taken by mouth once a day. The main goal of the study is to see how long participants can live without their cancer worsening, and there are also secondary goals related to overall survival and responses to the treatment. This study is currently recruiting participants of all genders, ages 65 to 74, and aims to help improve treatment options for this challenging condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Have a histopathological diagnosis (fresh or banked tumor biopsy sample collected within the last 3 years) consistent with locally advanced or metastatic conventional chondrosarcoma Grades 1, 2, or 3 and not eligible for curative resection.
• • Have at least one BICR-confirmed measurable lesion as defined by RECIST v1.1. Participants who have received prior radiation therapy are eligible provided measurable disease falls outside of the treatment field or within the field and has shown ≥20% growth in size since post-treatment assessment.
• • Have received 0 or 1 prior systemic treatment regimen in the advanced/metastatic setting for chondrosarcoma.
• * Have radiographic progression/recurrence of disease according to RECIST v1.1 defined as:
• • 1. Radiographic progression of disease (local and/or distant) documented by 2 imaging assessments performed no more than 6 months (±2 weeks) apart within 12 months before randomization.
• • OR
• • 2. Any recurrence of disease (local and/or distant) after complete surgical resection and documented by imaging within 6 months (±2 weeks) before randomization.
• • Have documented IDH1 gene-mutated disease (from a fresh tumor biopsy or the most recent banked tumor tissue available that was sourced from either a primary or metastatic tumor lesion) based on central laboratory testing (R132C/L/G/H/S mutation variants tested)
• • Have recovered from any clinically relevant sequelae and toxic effects of any prior surgery, radiotherapy, or other therapy intended for the treatment of cancer.
• Exclusion Criteria:
• • Are unable to swallow oral medication.
• • Pregnant or lactating women.
• • Are participating in another interventional study at the same time; participation in noninterventional registries or epidemiological studies is allowed.
• • Have received prior therapy with an IDH1 inhibitor
• • Have received systemic anticancer therapy \<2 weeks prior to randomization (for investigational or immune-based anticancer therapy \<4 weeks).
• • Have received radiotherapy \<2 weeks prior to randomization.
• • Have known symptomatic brain metastases requiring steroids \>10 mg per day prednisone (or equivalent). Participants with previously diagnosed brain metastases are eligible if they have completed their treatment and have recovered from the acute effects of radiation therapy or surgery prior to randomization, have discontinued or reduced corticosteroid treatment \<=10 mg per day for these metastases for at least 4 weeks and have radiographically stable disease of brain lesions for at least 3 months prior to randomization.
• • Have a history of another primary cancer, with the exception of: a) curatively resected non-melanoma skin cancer; b) curatively treated carcinoma in situ; or c) pT1-2 prostatic cancer Gleason score \<6 or d) participant is free of other primary solid or liquid tumor for ≥ 1 year prior to the start of study treatment and, in the opinion of the Investigator, the disease will not affect participant's outcome in the setting of current chondrosarcoma diagnosis.
• • Have had major surgery within 4 weeks prior to randomization.
• • Have significant active cardiac disease within 6 months prior to randomization, including New York Heart Association (NYHA) Class III or IV congestive heart failure; myocardial infarction; unstable angina; and/or stroke.
• • Have LVEF \<40% by ECHO scan (or by other methods according to institutional practice) obtained within 28 days prior to randomization.
• • Have a heart-rate corrected QT interval (using Fridericia's formula) (QTcF) ≥ 450 msec or other factors that increase the risk of QT prolongation or arrhythmic events (eg, heart failure, hypokalemia, family history of long QT interval syndrome). Participants with a bundle branch block combined with a prolonged QTcF interval may be permitted based on local cardiology assessment.
• • Have known medical history of progressive multifocal leukoencephalopathy (PML).