Effect of Mutations in T2DM Susceptibility Genes on the Expression of Susceptibility Genes in Patients With T2DM and Controls

Launched by THE AFFILIATED HOSPITAL OF XUZHOU MEDICAL UNIVERSITY · Feb 18, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how certain genetic changes, known as mutations, in people with Type 2 Diabetes Mellitus (T2DM) affect the way their body expresses genes related to this condition. The researchers are looking to understand if these mutations influence the levels of specific genes in the blood of both T2DM patients and healthy individuals. They will also compare these levels in pancreatic tissues from patients who have undergone surgery for pancreatic cancer to see if there are differences based on the genetic make-up.

To participate in the study, you need to be between 25 and 70 years old and have a certain level of blood sugar control, as measured by a test called Hemoglobin A1c (HbA1c). Healthy participants should be between 25 and 60 years old and in good health without any significant medical issues. You will be asked to provide blood samples, and if applicable, tissue samples from surgery will also be collected. This study is currently recruiting participants, and it’s a chance to contribute to important research that could help improve our understanding of Type 2 diabetes and its genetic factors.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. no drug therapy; 25 to 70 years old; Hemoglobin A1c (HbA1c) 7%-12%; BMI 20-35 kg/m2; Stable body weight (≤10% change within 3 months)（For newly diagnosed patients with T2DM）.
• • 2. 25 to 60 years old; BMI 19-26 kg/m2; in good health, with no abnormalities of motor system, digestive system, respiratory system, urogenital system, blood system, circulatory system, nervous/mental system, endocrine system, etc（For healthy subjects）.
• • 3. 20-80 years old; surgical resection of part or all of the pancreas; pancreatic lesions confirmed by enhanced CT or magnetic resonance (MR) examination or confirmed by intraoperative and postoperative pathology（For the patients in general surgical）.
• Exclusion Criteria:
• • 1. had taken antidiabetic drugs;
• • 2. had a history of pancreatic surgery;
• • 3. Complicated with severe organ lesions;
• • 4. Long-term use of drugs that affect pancreatic function.