A Mucosal Contouring Method Based on Swallowing-induced Breakthrough Pain for Radiation-induced Oropharyngeal Mucositis

Launched by NANFANG HOSPITAL, SOUTHERN MEDICAL UNIVERSITY · Feb 23, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new method for predicting and managing a painful condition called radiation-induced oropharyngeal mucositis, which can occur in patients with nasopharyngeal carcinoma (a type of cancer in the throat). The researchers are focusing on how well this new approach, which considers pain experienced when swallowing (known as swallowing-induced breakthrough pain), can help improve the care for patients undergoing radiation treatment. By using this method, they hope to better understand and predict how severe the mucositis will be, which could lead to more effective treatments and support for patients.

To be eligible for this trial, participants must be at least 18 years old, have been diagnosed with nasopharyngeal carcinoma, and be currently receiving radiation therapy or chemoradiotherapy. It's important that participants can provide informed consent and have clear records of their mucositis symptoms and associated pain. However, people with certain conditions like untreated dental issues, unstable heart problems, or a very low body weight may not be able to join the study. If someone participates, they can expect to contribute to important research that may improve treatment for future patients while closely monitoring their own symptoms and pain.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Provide informed written consent.
• • 2. Age ≥ 18 years.
• • 3. Histologically confirmed as nasopharyngeal carcinoma, and currently undergoing radical radiotherapy or chemoradiotherapy.
• • 4. Complete and continuous records of oral / oropharyngeal mucositis grading, and self-reported swallowing-induced breakthrough pain.
• Exclusion Criteria:
• • 1. Existence of poor oral hygiene, untreated dental or periodontal diseases, and metal dental restorations.
• • 2. Current untreated or unresolved conditions like unstable heart diseases requiring treatment, and poorly controlled diabetes mellitus.
• • 3. Body mass index (BMI) \<18.5.
• • 4. Unsuitable to participate in current study, according to researchers' assessment.