Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections

Launched by LOMA LINDA UNIVERSITY · Apr 9, 2024

Keywords

ClinConnect Summary

This clinical trial is studying whether using a diluted solution of povidone-iodine (a common antiseptic) during surgery can help reduce the risk of infections at the surgical site compared to using regular saline (saltwater) in patients undergoing emergency surgeries called laparotomies. The trial involves about 1,100 patients of all genders, aged between 18 and 80, who have specific types of wounds classified by the Centers for Disease Control as moderate to serious (class II and III).

To be eligible for this trial, participants must be in the right age range and scheduled for an exploratory laparotomy for the specified types of wounds. However, individuals who are pregnant, have a current infection in the abdominal area, are allergic to iodine, or have certain other health conditions won't be able to participate. Those who join the trial can expect to receive either the povidone-iodine treatment or the saline during their surgery, and researchers will then monitor their recovery to see which method is more effective in preventing infections. This study aims to find better ways to ensure safe outcomes for patients undergoing surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18 to 80 years of age
• • undergoing an exploratory laparotomy for Centers for Disease Control class II and III wounds
• Exclusion Criteria:
• • Pregnancy
• • Preoperative abdominal wall skin/soft tissue infection
• • Iodine allergy
• • Patients unlikely to survive beyond 30 days
• • Patients with mesh placement or placement of a foreign body except for drains