Prophylactic Effects for Preventing Surgical Site Infection in Third Molar Surgery

Launched by UJI TAKEDA HOSPITAL · Apr 12, 2024

Keywords

ClinConnect Summary

This clinical trial is looking into how effective a specific antibiotic, ampicillin, is in preventing infections after surgery to remove wisdom teeth, known as third molars. The researchers want to find out if giving this antibiotic for different lengths of time can help reduce the chances of getting an infection at the surgery site.

To be part of this study, participants need to be at least 20 years old and scheduled to have their wisdom teeth removed in a hospital setting under sedation. They should also be in generally good health, as determined by the American Society of Anesthesiologists. However, people who are pregnant, allergic to ampicillin, or have certain health issues that increase their risk for infection will not be eligible. If you join the study, you can expect to follow a specific treatment plan and contribute to important research that could help improve surgical care for others in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Minimum age of 20 years
• • American Society of Anesthesiologists (ASA) physical status of 1
• • Planned extraction of bilateral mandibular third molar with the necessity of bone removal based on panoramic radiography in an inpatient setting under IV sedation
• • Agreement to follow the study protocol
• Exclusion Criteria:
• • Pregnancy or suspicion of pregnancy
• • Allergy and/or contraindication to ampicillin
• • History of a known SSI risk factors, such as diabetes, steroid or immunosuppressant use, and endocarditis
• • Receiving any antibiotic therapy
• • Active infection of the third molars with pus, edema, and trismus