Trials
Search / Trial NCT06429657

Ketamine for Sedation in Severe Traumatic Brain Injury

Launched by HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE · May 23, 2024

Trial Information

Current as of February 19, 2025

Recruiting

Keywords

Tbi Severe Tbi Traumatic Brain Injury Sedation Ketamine

ClinConnect Summary

This clinical trial is studying the use of ketamine combined with propofol for sedation in patients who have experienced severe traumatic brain injuries (TBI). The goal is to see if this combination is safe and effective compared to the usual sedation methods currently used in the intensive care unit (ICU). Participants in this trial will be monitored closely to ensure their safety and comfort as they recover.

To be eligible for this study, participants must be adults aged 18 to 65 who have a severe TBI, indicated by a low score on the Glasgow Coma Scale (which measures consciousness). They also need to have an intracranial pressure monitor placed to track brain pressure. However, individuals with serious heart problems, pregnant women, prisoners, or those allergic to ketamine or propofol cannot participate. If someone joins the trial, they can expect to receive sedation through the study drugs while being carefully looked after in the ICU.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Adults 18-65 years of age
  • Severe traumatic brain injury (TBI), with a Glasgow Coma Scale (GCS) ≤ 8, requiring intracranial monitoring
  • Placement of intracranial pressure monitor
  • Receiving treatment in an intensive care unit (ICU)
  • Exclusion Criteria:
  • Significant cardiovascular disease with recent coronary intervention
  • Pregnancy
  • Prisoners
  • Known allergy to ketamine or propofol

About Henry M. Jackson Foundation For The Advancement Of Military Medicine

The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) is a non-profit organization dedicated to advancing military medicine through research, education, and innovation. Established in 1983, HJF collaborates with the U.S. military, academic institutions, and industry partners to facilitate the development and implementation of medical solutions that enhance the health and well-being of service members and their families. Through its support of clinical trials and scientific research initiatives, HJF plays a pivotal role in translating cutting-edge medical discoveries into effective treatments, ultimately contributing to the improvement of healthcare delivery within military and civilian populations.

Locations

Fort Sam Houston, Texas, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0