The Association Between Respiratory Effort Parameters During the First 48 Hours With Clinical Outcomes in Mechanically Ventilated Patients: A Prospective Observational Study.
Launched by RAMATHIBODI HOSPITAL · May 25, 2024
Trial Information
Current as of February 19, 2025
Completed
Keywords
ClinConnect Summary
Recently, the lung and diaphragm protective strategy is an important consideration when providing mechanical ventilation to critically ill patients. Although mechanical ventilation can be life-saving, improper management can cause harm. The harmful mechanical ventilator setting can result from over-assisted or under-assisted ventilation. Over-assisted ventilation can be caused by too much ventilatory support or calming down patients with high dosages of sedative drugs or muscle relaxants, which negatively affect the operation of the diaphragm leading to diaphragm muscle atrophy and weakness...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • 1. Participants must be aged between 18-75 years.
- • 2. Admitted to the critical care and semi-critical care units (ICUs) of the Department of -Internal Medicine, Ramathibodi Hospital (ICUs 9IC, 8IK, and 7NW).
- 3. Patients with acute respiratory failure admitted to the hospital with the following conditions within the first 48 hours:
- • PaO2/FiO2 greater than 150 or
- • PaO2 less than 60 mm Hg or
- • SaO2 less than 90 mm Hg or
- • Work of breathing more than 25 breaths per minute or requiring respiratory muscle assistance
- • 4. Permission obtained from the attending physician.
- • 5. Research participants or their direct relatives must sign informed consent.
- • 6. The research can commence and data can be recorded within 48 hours after the patient has received treatment with the mechanical ventilator.
- Exclusion Criteria:
- • 1. Admitted to the hospital or had a history of hospital admission within a month before recruitment.
- • 2. History of cardiovascular or cerebrovascular events within the last 12 months.
- • 3. Pregnant.
- • 4. Terminal-stage cancer patient, terminal illness-stage of disease who desire palliative care.
- • 5. Active neurological or muscular disorders affecting stability.
- • 6. Brain coma, brain death, or status epilepticus.
- • 7. Severe mental health conditions, including active depression with psychotic features, bipolar disorder, or schizophrenia.
- • 8. Uncontrolled thyroid conditions within a month before recruitment.
- • 9. Uncorrectable patients with severe hypoxemia (P/F ratio less than 150).
- • 10. Patients receiving neuromuscular blocking agents.
Trial Officials
Mr. Phruet Soipetkasem, Critical care doctor
Principal Investigator
Doctor of Critical care medicine Ramathibodi hospital
Pongdhep Theerawit, Assoc. Prof.
Study Chair
Head of Critical care medicine Ramathibodi hospital
Yuda Sutherasan, Assoc. Prof.
Study Director
Clinical professor of Pulmonary and Critical care medicine Ramathibodi hospital
Mr. Detajin Junhasavasdikul, Asst.Prof.
Study Director
Clinical professor of Pulmonary and Critical care medicine Ramathibodi hospital
About Ramathibodi Hospital
Ramathibodi Hospital, a leading medical institution in Thailand, is renowned for its commitment to advancing healthcare through innovative research and clinical trials. Affiliated with Mahidol University, the hospital combines cutting-edge technology with expert clinical care, fostering an environment conducive to scientific inquiry and patient-centered research. With a focus on a wide array of medical disciplines, Ramathibodi Hospital aims to enhance treatment protocols and improve patient outcomes by actively participating in clinical trials that adhere to the highest ethical standards and regulatory compliance. Its collaborative approach involves multidisciplinary teams dedicated to exploring new therapeutic avenues and translating research findings into clinical practice.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Bangkok, , Thailand
People applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Discussion 0