Neutrophil Extracellular Traps in Different Forms of Systemic Sclerosis

Launched by CHU DE REIMS · Jun 12, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a condition called systemic sclerosis (SSc), a disease that affects the skin and other organs by causing hardening and damage. Researchers are particularly interested in understanding the role of immune cells called neutrophils and their web-like structures known as Neutrophil Extracellular Traps (NETs). These NETs may play a part in the disease and could help explain why some patients experience complications. The trial aims to explore how these immune responses are regulated in people with SSc compared to those with other similar diseases or healthy volunteers.

To participate in this study, individuals must be aged 18 or older and meet specific criteria. They can include patients with systemic sclerosis or other connective tissue diseases who are being treated at the university hospital in Reims, or healthy volunteers without any history of autoimmune diseases. Participants will be asked to consent to take part in the study and may need to undergo blood tests. This research could lead to a better understanding of systemic sclerosis and potentially improve treatment options for those affected by this condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• \*For patients of group 1:
• • Patients with systemic sclerosis (ACR-EULAR Criteria)
• • Patients taking care of in internal medicine or in dermatology department's of the university hospital of Reims
• • Patients consenting to participate to the study
• • Patients enrolled in the national healthcare insurance program
• For patients of group 2:
• • Patients with other connective tissue disease (ACR specific-disease criteria)
• • Patients taking care of in internal medicine or in dermatology department's of the university hospital of Reims
• • Patients consenting to participate to the study
• • Patients enrolled in the national healthcare insurance program
• • For patients of group 3 (healthy volunteers)
• • Patients eligible for blood donation (blood donation regulation criteria of January 11th 2022 decree)
• • Patients without medical history of autoimmune systemic or chronic inflammatory systemic disease,
• • Patients without current or past neoplasy disease,
• • Patients without chronic metabolic pathology
• • Patients without treatment by anti inflammatory or corticotherapy for the last 15 days,
• • Patients without infectious pathology or inflammatory acute for the last 15 days
• • Patients consenting to participate to the study
• Exclusion Criteria for patients of all groups:
• • Patients/Healthy volunteers under 18 years old
• • Patients/Healthy volunteers protected by the law
• • Patients/Healthy volunteers not consenting to participate to the study after information
• • Patients with inflammatory pathology or infectious acute intercurrent pathology in the last 15 days before inclusion
• • Pregnant or breastfeeding women