The Effect of Nocturnal Dexmedetomidine on Postoperative Sleep Quality and Fatigue After Major Surgery in Elderly Patients: DEXSLEEP Study

Launched by ZIEKENHUIS OOST-LIMBURG · Jun 24, 2024

Keywords

ClinConnect Summary

The DEXSLEEP study is a clinical trial that aims to find out if giving a medication called dexmedetomidine at night can help improve sleep quality and reduce fatigue in older patients after they have major lung surgery. Many patients experience tiredness and difficulty sleeping after surgery, which can affect their recovery. This study will compare the effects of dexmedetomidine with a placebo (a treatment that doesn't contain the active medication) to see if it really helps patients feel better and regain their strength after surgery.

To participate in this study, patients need to be 60 years or older and scheduled for thoracoscopic lung surgery, which is a type of minimally invasive surgery on the lungs. Participants will receive either dexmedetomidine or a placebo during their recovery period. It's important to note that people with certain health conditions, like severe heart problems or low blood pressure, won't be able to take part in this study. Overall, this research could provide valuable insights into how we can help older patients recover more effectively after surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • aged 60 years or older;
• • scheduled for thoracoscopic lung surgery.
• Exclusion Criteria:
• • lack of informed consent or inability to give informed consent;
• • ≥ 2nd-degree atrioventricular block without pacemaker;
• • uncontrolled hypotension (blood pressure \< 90/60 mmHg);
• • known hypersensitivity to dexmedetomidine or to any of the excipients;
• • acute cerebrovascular conditions;
• • urgent, not elective surgery.