Retinal Microvascularization in OCT-angiography and Systemic Diseases

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DIJON · Sep 23, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the health of small blood vessels in the retina (the back part of the eye) and how they relate to systemic diseases, which are illnesses that affect the whole body, like heart disease or inflammatory conditions. Researchers believe that by examining the retinal blood vessels using a technique called optical coherence tomography-angiography (OCT-A), they can find early signs of these diseases before they become more serious. This could help doctors decide on the best treatments for patients and improve health outcomes.

To participate in this trial, you may be eligible if you have a systemic vascular disease, are at high risk for heart problems, or have had preeclampsia during pregnancy. Healthy individuals without any systemic or vascular diseases can also join. Participants will undergo painless eye scans to create a database of images, which will help researchers track changes in retinal blood vessel health over time. This study aims to enhance early diagnosis and monitoring of systemic diseases, ultimately benefiting patient care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • For the \"patients with systemic vascular disease\" group
• • Patients who have given oral, free and informed consent
• * Patients with either :
• • systemic vascular pathology
• • high cardiovascular risk
• • inflammatory vascular pathology
• • preeclampsia during pregnancy
• • The study will also be offered to patients who have already had an OCT-A examination as part of their routine care, in order to follow them over time.
• • For the \"healthy control\" group
• • Patients who have given free, oral and informed consent
• • Patients with no prior systemic or vascular inflammatory pathology, and no high cardiovascular risk
• • Non-diabetic patients
• • Pregnant patients with risk-free pregnancies recruited from the gynecology department of CHU Dijon Bourgogne OR
• • Adult patients without maculopathy recruited from the Ophthalmology Department of CHU Dijon Bourgogne
• Exclusion Criteria:
• • For the \"patients with systemic vascular disease\" group
• • Ophthalmological history in both eyes (vascular and degenerative macular pathologies)
• * Protected patient :
• • Minor patient
• • Patient under legal protection (guardianship, curatorship, court order)
• • Patient unable to give consent Person not affiliated to a social security scheme
• • Breast-feeding women
• • Person with a contraindication to Tropicamide
• • OCT-A signal strength \< 7
• • For the \"healthy control\" group
• • Any pathology studied in the case group
• • Ophthalmological history in both eyes (vascular and degenerative macular pathologies)
• • Type 1 or type 2 diabetes
• • Person with a contraindication to Tropicamide
• * Protected person :
• • Minor
• • Person under legal protection (guardianship, curatorship, court order)
• • Person unable to give consent
• • Person not affiliated to a social security scheme
• • Breast-feeding women
• • OCT-A signal strength \< 7