A Randomized Controlled Trial to Test the Effects Oxytocin and Vibration Have on Heat Pain Threshold After UV-B Burn

Launched by WAKE FOREST UNIVERSITY HEALTH SCIENCES · Oct 17, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at whether a hormone called oxytocin can help increase pain tolerance when combined with vibration therapy in people who have mild sunburns. The researchers want to see if these treatments can make it easier to handle heat pain in the sunburned area of the skin.

To participate in this study, you need to be between 18 and 55 years old, in generally good health, and have light to medium skin tones (Fitzpatrick Scale ratings I to III). Unfortunately, if you have a history of skin cancer or certain medical conditions, such as chronic pain or certain heart issues, you would not be eligible to join. If you qualify, you will receive treatments and be monitored by the research team to see how your body responds. This study is currently recruiting participants, and it aims to find new ways to help people manage pain from sunburn.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female \> 18 and ≤55 years of age, Body Mass Index (BMI) \<40
• • Generally in good health as determined by the Principal Investigator based on prior medical history, and as assessed to be American Society of Anesthesiologists physical status 1, 2, or 3
• • Fitzpatrick Scale rating I through III
• Exclusion Criteria:
• • History of skin cancer
• • Dark enough skin complexion that would make it infeasible to determine the minimal erythematous dose of UV-B irradiation. Anyone Fitzpatrick Scale score \>3 will be excluded
• • Neuropathy, chronic pain (located in any body location that is being treated), diabetes mellitus, or taking benzodiazepines or pain medications on a daily basis
• • Pregnancy or currently breast feeding
• • Subjects with current or history of ventricular tachycardia, atrial fibrillation or prolonged QT interval
• • Subjects with past or current history of hyponatremia or at risk for hyponatremia; anyone taking thiazide diuretics, loop diuretics, combination diuretics, lithium, carbamazepine, enalapril, Ramipril, celecoxib, temazepam, gliclazide, glimepiride, glibenclamide, glipizide, omeprazole, pantoprazole, desmopressin, SSRI's, MAOI, or the recreational drug ecstasy
• • Subjects with a known latex allergy