Effect of Force Magnitude on Canine Retraction and Gingival Crevicular Fluid Proteome

Launched by UCONN HEALTH · Oct 30, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how different levels of pressure used in braces affect the movement of canine teeth (the pointed teeth next to your front teeth) and the surrounding gum tissue. Specifically, researchers want to find out if using light or heavy force changes how quickly these teeth move during treatment for tooth crowding. To do this, they will collect samples of gum fluid, take dental molds, and use x-rays to monitor changes in the teeth as they move.

The trial is looking for healthy participants aged 11 to 16 who have a full set of teeth (except for their second molars) and need to have at least one upper premolar removed to help with their orthodontic treatment. Participants should be able to read and understand English and give permission for themselves or their child to join the study. If you or your child qualifies, you can expect to contribute to important research that may help improve orthodontic treatments for others in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy patient, non-smoker
• • Age: 11 - 16 years of age, inclusive.
• • A full complement of dentition (central incisor to 1st molar) in the four quadrants, except second molars
• • Patients requiring at least upper bilaterally maxillary 1st premolar extraction as a treatment plan (Class I bimaxillary protrusion/ crowding or Class II maxillary dentoalveolar protrusion/ crowding)
• • At least 5 mm of space left between canine and 2nd premolar to be closed at the time of canine retraction
• • At least six months after the extraction of first premolars and in a 0.019 x 0.025-inch stainless steel archwire in the maxilla
• • The ability to read and understand English and to provide informed consent
• Exclusion Criteria:
• • Patients under 11 years of age and over the age of 16.
• • Non-extraction treatment plan
• • Extraction of maxillary tooth other than first premolars bilaterally.
• • Evidence of poor oral hygiene
• • Evidence of previous root resorption
• • Missing or impacted tooth in any of the quadrant except 3rd molars.
• • Medical issues that affect tooth movement
• • Inability to provide oral and written consent to participate.
• • Patient on medications that may alter bone metabolisms like bisphosphonates, oral contraceptives, or PTH (parathyroid hormone)
• • Chronic illness or syndromic patients.
• • Pregnant women, prisoners, and decisional impaired