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Search / Trial NCT06874686

Minimally Invasive Surgical Intervention for Hirschsprung's Disease in Pediatric Patients

Launched by NATIONAL CHILDREN'S HOSPITAL, VIETNAM · Mar 8, 2025

Trial Information

Current as of April 29, 2025

Completed

Keywords

Aganglionic Minimally Invasive Laparoscopic Pediatric Single Incision Hirschsprung Hirschsprung Disease

ClinConnect Summary

Hirschsprung's disease (HD) is a congenital disorder caused by the absence of enteric ganglion cells in the distal bowel, leading to functional obstruction, delayed meconium passage in neonates, and defecation difficulties. If left untreated, HD can result in life-threatening complications such as Hirschsprung-associated enterocolitis and severe bowel dysfunction. Surgical intervention is necessary to remove the aganglionic segment and restore normal bowel function. In recent years, minimally invasive laparoscopic techniques have gained preference over open surgery due to their potential to...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • All pediatric patients (under 18 years old) diagnosed with Hirschsprung's Disease, admitted to National Children's Hospital between January 2017 and December 2023.
  • Patients exhibiting clinical signs and symptoms consistent with Hirschsprung's Disease, with imaging findings confirming the diagnosis. If imaging was inconclusive but clinical suspicion remained high, patients were still considered for surgical evaluation and management.
  • Underwent minimally invasive laparoscopic pull-through surgery, either conventional multi-port (CLP) or single-incision (SILS).
  • Postoperative Follow-up Data Availability: Patients with documented short-term postoperative outcomes, including bowel function recovery, complications, or reoperation rates.
  • Exclusion Criteria:
  • Clinical instability requiring emergency open laparotomy due to peritonitis, intestinal perforation, or other life-threatening conditions.
  • Biopsy findings inconsistent with Hirschsprung's Disease, ruling out the diagnosis.
  • Incomplete Medical Records: Patients with missing key data, such as operative details, pathology reports, or follow-up outcomes, that could compromise study integrity

About National Children's Hospital, Vietnam

National Children's Hospital, Vietnam, is a leading pediatric healthcare institution committed to advancing child health through innovative research and clinical trials. With a focus on improving treatment outcomes and enhancing healthcare delivery for children, the hospital collaborates with international and local partners to conduct rigorous clinical studies across various pediatric specialties. Its multidisciplinary team of healthcare professionals and researchers is dedicated to fostering a safe and ethical environment for clinical research, ensuring the highest standards of care and scientific integrity in all trials. Through its initiatives, National Children's Hospital aims to contribute significantly to the global body of pediatric knowledge and improve health outcomes for children in Vietnam and beyond.

Locations

Hanoi, , Vietnam

Patients applied

0 patients applied

Trial Officials

Quang T Nguyen, M.D.

Principal Investigator

Department of Pediatric Surgery, The National Hospital of Pediatrics, Hanoi, Vietnam

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported