The Effect of an Antioxidant Gel Compared to Chlorhexidine Gel During the Soft Tissue Healing Process: A Randomized Controlled Clinical Trial

Launched by KUWAIT UNIVERSITY · Mar 19, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effects of two different gels—an antioxidant gel and chlorhexidine gel—on healing after a dental procedure called scaling and root planing (SRP), which is used to treat serious gum disease known as periodontitis. The goal is to see which gel helps patients heal better and reduces complications after the procedure by looking at certain markers in the body that indicate inflammation and healing.

To participate in this trial, patients need to have Stage 3 or 4 periodontitis, which means they have significant gum disease with specific symptoms like bleeding gums and deep pockets around the teeth. However, individuals with milder gum issues, certain health conditions (like diabetes or cancer), smokers, or those who have recently used specific medications are not eligible. Participants in the trial will use one of the two gels after their dental treatment, and researchers will monitor their healing progress. This study aims to help dentists choose the best postoperative care to improve healing and long-term gum health for their patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with Stage 3 or 4 periodontitis would be invited to participate in this study.
• • The following parameters will be used for the diagnosis of periodontitis: (a) presence of bleeding on gentle probing; (b)probing depth (PD) \>6mm; and (c) marginal bone loss (MBL) of at least 3.
• Exclusion Criteria:
• • Patients will be excluded from the study if they present with gingivitis alone, are currently using oral contraceptives, have systemic conditions such as diabetes or cancer, or are smokers (including those who quit within the past 6 months).
• • Recent antibiotic use within the last 3 months, NSAID or bisphosphonate use within the last 90 days, and any use of chlorhexidine in the past 6 months.