Surfactant Derived Protocol in Heart Failure
Launched by CENTRO CARDIOLOGICO MONZINO · Mar 19, 2025
Trial Information
Current as of April 29, 2025
Completed
Keywords
ClinConnect Summary
Pulmonary surfactant is a highly surface-active lipoprotein complex that forms a thin film lining the alveolar and terminal airway surfaces. Its primary physiological function is to reduce surface tension at the air-liquid interface, stabilizing the alveoli and preventing their collapse at the end of expiration. Both the lipid and protein fractions of surfactant are synthesized by type II pneumocytes and stored in lamellar bodies-intracellular organelles where surfactant is secreted through the fusion of their outer membrane with the apical plasma membrane of the cell, releasing surfactant ...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Heart failure diagnosis
- • Left ventricular ejection fraction \<40%
- • Stable clinical condition
- Exclusion Criteria:
- • Relevant comorbidities
- • usual contraindications to cardiopulmonary testing.
About Centro Cardiologico Monzino
Centro Cardiologico Monzino (CCM) is a leading cardiovascular research and treatment facility based in Milan, Italy, renowned for its commitment to advancing cardiac care through innovative clinical trials and cutting-edge research. Affiliated with the Italian Ministry of Health, CCM specializes in a comprehensive range of cardiovascular services, including diagnostics, interventional cardiology, and rehabilitation. The institution is dedicated to fostering collaboration among healthcare professionals, researchers, and patients to enhance the understanding of cardiovascular diseases and improve therapeutic outcomes. With a focus on translating scientific discoveries into clinical practice, CCM plays a pivotal role in shaping the future of cardiovascular medicine.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Milano, , Italy
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported