Surfactant Derived Protocol in Heart Failure

Launched by CENTRO CARDIOLOGICO MONZINO · Mar 19, 2025

Keywords

ClinConnect Summary

Pulmonary surfactant is a highly surface-active lipoprotein complex that forms a thin film lining the alveolar and terminal airway surfaces. Its primary physiological function is to reduce surface tension at the air-liquid interface, stabilizing the alveoli and preventing their collapse at the end of expiration. Both the lipid and protein fractions of surfactant are synthesized by type II pneumocytes and stored in lamellar bodies-intracellular organelles where surfactant is secreted through the fusion of their outer membrane with the apical plasma membrane of the cell, releasing surfactant ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Heart failure diagnosis
• • Left ventricular ejection fraction \<40%
• • Stable clinical condition
• Exclusion Criteria:
• • Relevant comorbidities
• • usual contraindications to cardiopulmonary testing.