Effectiveness of Oscillation on Postoperative Pulmonary Complications After Elective Postcardiac Surgery

Launched by SOUTHEAST UNIVERSITY, CHINA · Mar 24, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating whether a special type of treatment called continuous high-frequency oscillation therapy can help reduce lung complications after elective heart surgery. These complications, known as postoperative pulmonary complications (PPCs), can occur when patients have trouble with their lungs during recovery. The goal of the study is to find better ways to care for patients' lungs after surgery, potentially leading to improved recovery outcomes.

To participate in this trial, you need to be an adult (18 years or older) who is scheduled for elective cardiac surgery and have at least one risk factor that could lead to lung problems, such as being 75 years or older, having a history of chronic lung issues, or being a heavy smoker. During the study, participants will receive either the oscillation therapy or standard care, and researchers will monitor the effects on their lung health after surgery. It's important to note that some people may not be eligible for this trial if they have certain medical conditions or complications at the time of surgery. If you think you might qualify, please talk to your doctor for more information.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients (18 years or older) undergoing elective cardiac surgery will be included. Participants must provide informed consent upon ICU admission and have at least one risk factor for PPCs, including age ≥ 75 years, American Society of Anesthesiologists (ASA) score ≥ 2, history of chronic obstructive pulmonary disease (COPD) stage ≥ 2 or asthma (moderate to severe), current heavy smoking or heavy smoking history within the past 6 months, obstructive sleep apnea, frailty index \> 0.21 or body max index (BMI) ≥ 30 kg/m².
• Exclusion Criteria:
• • Patients will be excluded if they have contraindications for oscillation treatment (e.g., untreated tension pneumothorax); have pneumothorax or air leak syndrome at entry; require more than 2 μg/kg/min of norepinephrine; have been diagnosed with pneumonia within 2 weeks prior to surgery; have refractory arrhythmia at entry; have a left ventricular ejection fraction \< 35%; have mean pulmonary artery pressure (mPAP) \> 35 mmHg; are postoperative from spinal surgery within the past 2 weeks; require a ventricular assist device; have renal failure requiring continuous renal replacement therapy (CRRT) at entry; are planned for re-operation within 48 hours or have undergone organ transplantation.