Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Adults

Launched by RUSH UNIVERSITY MEDICAL CENTER · May 27, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two different methods to help critically ill adults who are on mechanical ventilation safely breathe on their own again. The goal is to compare "pressure support ventilation" (PSV) and "automatic tube compensation" (ATC) during something called a spontaneous breathing trial (SBT). An SBT is a test that helps doctors decide if it's safe to remove a breathing tube from a patient who has been on a ventilator for more than 24 hours.

To participate in this trial, patients need to be 18 years or older, currently receiving invasive mechanical ventilation in the intensive care unit (ICU), and able to pass a screening for the SBT. However, some individuals may not be eligible, such as those who have a "do not intubate" order, are pregnant, have a tracheostomy, or are enrolled in another clinical trial that might affect the study. If someone does join the trial, they can expect to undergo tests to see which method helps them breathe on their own more effectively, contributing to important research that could improve care for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Admitted to intensive care unit (ICU)
• • Age 18 years or older
• • Requiring invasive mechanical ventilation for at least 24 hours
• • Pass spontaneous breathing trial screen criteria
• Exclusion Criteria:
• • Clinical decision made not to proceed with extubation regardless of spontaneous breathing trial (SBT) results
• • Do not intubate (DNI) order
• • Presence of tracheostomy
• • Pregnancy
• • Known prisoner
• • Immediate need for extubation, self-extubation, or unplanned extubation that precludes safe performance of study procedures
• • Enrolled in another clinical trial that impacts ventilator weaning or liberation