The Novel Special Light for Endotracheal/Bronchial Lesions.

Launched by SHANGHAI CHEST HOSPITAL · Jun 17, 2025

Keywords

ClinConnect Summary

This is a single-center, observational study at Shanghai Chest Hospital in Shanghai, China. Researchers want to see if new imaging lights used during bronchoscopy (special lights called TXI, NBI, and RDI) can help doctors tell whether lesions inside the windpipe or airways are benign (not cancer) or cancerous. About 400 adults who already have endotracheal or bronchial lesions and need bronchoscopy may be invited to join. To participate, you’d need to be 18 or older, have findings on imaging suggesting a central lung lesion that needs bronchoscopy, and be able to consent and complete follow-up; people who are pregnant, have no lesion, or have other safety concerns for bronchoscopy would not be eligible.

Participants will undergo bronchoscopy using the new special lights along with standard light, to see how well these lights identify and classify lesions, with histopathology (tissue analysis) used as the gold standard for comparison. A secondary goal is to establish how to diagnose and grade lesions using the special lights. The main findings are planned to be evaluated within about one month after the procedure. This study is led by Dr. Jiayuan Sun at Shanghai Chest Hospital, and results will come from a real-world, diagnostic-focused approach rather than testing a new treatment. Enrollment started in 2024 and is ongoing, with an estimated completion by late 2026.

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Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥18 years old;
• • 2. Patients with chest imaging findings indicating central lung lesions requiring further bronchoscopy;
• • 3. Patients with neoplasm in the lumen that could be biopsied by bronchoscopy or operated;
• • 4. Patient who has good compliance and sign informed consent;
• • 5. The investigator believes that the subjects can understand the process of the clinical study, are willing and able to complete all the research procedures and follow-up visits, and cooperate with the research procedures.
• Exclusion Criteria:
• • 1. Pregnant or lactating women;
• • 2. No endotracheal/bronchial lesions were detected by bronchoscopy;
• • 3. Allergic reaction to narcotic drugs in previous medical history;
• • 4. The investigator believes that the subject is not suitable for bronchoscopy;
• • 5. High-risk diseases or other special conditions for which the investigator considers the subjects unsuitable for clinical trials.