The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery

Launched by KING ABDULLAH INTERNATIONAL MEDICAL RESEARCH CENTER · Jul 21, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how giving two medicines—low-dose epinephrine and tranexamic acid—affects people having knee replacement surgery. The researchers want to see if these medicines can help reduce blood loss during and after the surgery, lower the risk of blood clots, and possibly shorten the time patients need to stay in the hospital.

People who are having knee joint replacement surgery may be eligible to join this study, as long as they have complete medical records and do not have certain health problems like severe kidney or liver disease, blood clotting disorders, recent heart attacks or strokes, heart failure, certain eye conditions, or allergies to the study medicines. Pregnant or breastfeeding women are also not eligible. If you join, you can expect careful monitoring during the surgery and recovery to see how the medicines affect your outcomes. This study is currently recruiting patients, and it includes adults of all genders.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients undergoing knee joint arthroplasty.
• • Saudi and Non-Saudi Patient.
• • Patients who have Complete medical record.
• Exclusion Criteria:
• • End stage renal disease
• • Liver cirrhosis
• • Coagulopathy
• • Pre-operative Hgb \<10 5.
• • History of cerebrovascular accident or myocardial infarction in past 12 months.
• • History of Heart failure.
• • History of arrhythmia.
• • History of pheochromocytoma, thyrotoxicosis and glaucoma.
• • Pregnancy or breast feeding
• • History of Deep venous thrombosis or pulmonary embolism
• • Allergy to epinephrine or tranexamic acid