Haemdall: Developing a Quantitative MRI Biomarker of Infratentorial Superficial Siderosis of the Central Nervous System

Launched by PERSPECTUM · Jul 31, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring a new way to use MRI scans to measure iron buildup on the surface of the brain in people with a condition called superficial siderosis. This condition happens when small amounts of bleeding cause iron to collect around the brain, which can lead to symptoms like hearing loss, problems with walking and balance, and difficulties with memory and thinking. The study aims to see if the amount of iron seen on the MRI matches up with these common symptoms.

Adults 18 years and older who have been diagnosed with superficial siderosis may be eligible to take part, as well as healthy adults without neurological conditions for comparison. To join, participants need to be able to understand and communicate in English and give their consent. During the study, participants will have MRI scans and undergo tests to check their hearing, balance, walking, and cognitive abilities. People who cannot have an MRI, for example due to certain medical devices or severe claustrophobia, will not be able to participate. This study is not yet recruiting but aims to improve how doctors understand and track superficial siderosis in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Superficial siderosis cohort:
• • Male or female adults of 18 years of age or older with a confirmed diagnosis of superficial siderosis
• • Participants who have the capacity and a level of English proficiency that allows him/her to communicate well with the Investigator, understand and comply with the requirements of the investigation, read all participant facing documentation, as well as read and sign the informed consent form.
• • Participants willing and able to give informed consent for participation in the investigation
• Healthy cohort:
• • Male or female over 18 years of age without a diagnosis of a neurological disorder
• • Participants who have the capacity and a level of English proficiency that allows him/her to communicate well with the Investigator, understand and comply with the requirements of the investigation, read all participant facing documentation, as well as read and sign the informed consent form.
• • Participants willing and able to give informed consent for participation in the investigation
• Exclusion Criteria:
• • The participant may not enter the investigation if they have any contraindication to magnetic resonance imaging (including pregnancy, extensive tattoos, pacemaker, shrapnel injury or metallic unfixed implanted devices, metallic fragments, severe claustrophobia and cochlear implants)
• • Any other cause, including a significant disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the investigation, or may influence the result of the investigation, or the participant's ability to participate in the investigation
• • Participants who do not demonstrate the capacity to understand the investigation information or provide informed consent