A Comparative Study Between Dexmedetomidine Versus Methylprednisolone on Induced Inflammatory Response in Patients Undergoing On-pump CABG

Launched by AIN SHAMS UNIVERSITY · Jul 31, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two different medicines, dexmedetomidine (also called Precedex) and methylprednisolone (also called Solu-Medrol), to see how well they reduce inflammation in patients having heart bypass surgery using a heart-lung machine (called on-pump CABG). The study will look at how these drugs affect the body’s inflammatory response, as well as how they impact heart and brain function after the surgery when patients are taken off breathing support.

Adults aged 21 to 60 who are scheduled for this type of heart surgery and are generally in moderate health (classified as ASA Class II or III) may be eligible to join. People who have certain health conditions like severe liver or kidney problems, poor heart function, recent infections, or who are pregnant will not be able to participate. If you join, you can expect close monitoring of your inflammation levels and heart and brain health after surgery to understand which medicine works better to reduce stress on the body. This study is not yet recruiting participants but aims to find safer ways to help patients recover from heart surgery with fewer complications.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age 21-60 years.
• • 2. Sex: Both sexes.
• • 3. American Society of Anaesthesiologists (ASA) Physical Status Class II, and III.
• • 4. Scheduled for CABG on cardio-pulmonary bypass.
• Exclusion Criteria:
• • 1. Declining to give a written informed consent.
• • 2. History of allergy to the medications used in the study.
• • 3. Psychiatric disorders.
• • 4. Significant cognitive dysfunction.
• • 5. American Society of Anesthesiologists (ASA) Physical Status Class IV.
• • 6. Chronic liver or kidney disease.
• • 7. Poor systolic function ( Ejection fraction \< 40% ).
• • 8. Pregnancy.
• • 9. Redo CABG.
• • 9.Infection during the week preceding surgery white blood cell count over 11,000 mm3 10.Pre-operative use of antibiotics or corticosteroids.