Subgrouping SLE - a New Approach to Understand the Pathogenesis and Improve Treatment

Launched by REGION STOCKHOLM · Jul 28, 2025

Keywords

ClinConnect Summary

This study is looking at people with systemic lupus erythematosus (SLE), a condition where the immune system attacks the body, to better understand different types or “subgroups” of the disease. Researchers want to see if these subgroups, identified by certain antibodies, genes, or other markers in the body, explain why some people with SLE are more likely to develop early heart and blood vessel problems. They also aim to learn more about how specific immune factors relate to kidney problems and blood clotting issues in SLE. By comparing these patient groups to each other and to healthy people without SLE, the study hopes to find new ways to understand and treat the disease.

If you have been diagnosed with SLE and meet certain criteria, you may be eligible to take part. Participants will be asked to visit the clinic where a nurse and doctor will review your health history, take some measurements, and ask you to complete questionnaires about your quality of life. Blood, urine, and saliva samples will also be collected and stored for further study. The study is open to adults of all genders who can understand the information provided and agree to participate. This research does not involve new treatments but focuses on learning more about the disease to improve future care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • SLE according to criteria (ACR82 or SLICC 2012) and consenting to participate
• Exclusion Criteria:
• • Not possible to read and understand patient information due to language barriers or psychological/psychiatric disorders Not consenting
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