ARS vs ARS With Arthrocentesis and PRP Injection in DDWR

Launched by CAIRO UNIVERSITY · Aug 4, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at two treatments for people who have a condition called TMJ disc displacement with reduction, which affects the joint that connects your jaw to your skull. This condition can cause jaw pain, clicking sounds when you open or close your mouth, and difficulty opening your mouth fully. The study will compare the use of a special mouth splint called an anterior repositioning splint (ARS) alone versus the splint combined with two additional treatments: a gentle joint washing procedure (arthrocentesis) and an injection of platelet-rich plasma (PRP), which is a substance made from your own blood that may help healing.

People who might be able to join the study are those experiencing typical TMJ symptoms like pain, clicking, or limited jaw movement, but who do not have certain health problems such as blood disorders, uncontrolled diseases, rheumatoid arthritis, or infections near the jaw. Participants in the study will receive either the splint alone or the splint plus the joint washing and PRP injection, and researchers will observe how well these treatments help improve their symptoms. The trial has not started recruiting yet, and it is open to all genders. This study aims to find out if adding the joint washing and PRP injection provides better relief than the splint alone.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients suffering from internal derangement anterior disc displacement
• • Mouth Opening: Limited range of motion or difficulty with full mouth opening
• • Symptoms: Patients who report typical symptoms of TMJ dysfunction, such as pain, discomfort, or clicking sounds in the joint, especially when opening or closing the mouth.
• • Clicking: Audible clicking.
• • Pain: Pain or tenderness around the TMJ, often radiating to the ear, temple, or neck.
• Exclusion Criteria:
• • Blood dyscrasias and Uncontrolled systemic diseases.
• • Rheumatoid Arthritis.
• • Infection in the pre-auricular area.