Metabolic and Epigenetic Impact of FAAH Inhibitors and OEA

Launched by NICOLE STEVENS, PHD · Aug 11, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether a dietary supplement made from natural ingredients—oleoylethanolamide (OEA), ginger extract, and lavender essential oil—can affect certain markers in the blood and overall health in healthy adults. The researchers want to see if taking this supplement twice a day for 12 weeks changes gene activity, protein levels in the blood, body measurements like weight and waist size, blood pressure, heart rate, and how participants feel about their health. They will also check if taking the supplement is safe by monitoring lab tests and any side effects.

Adults between 18 and 64 years old who have a body mass index (BMI) between 25 and 30 (which means they are slightly overweight) may be eligible to join. Participants should live near the study center or be able to travel there for three visits over 12 weeks, during which they will provide blood and urine samples, have their body measurements taken, and complete health surveys. People must be willing to avoid other essential oils or similar supplements for the study’s duration, keep their diet and lifestyle consistent, limit alcohol to moderate levels, and avoid smoking or recreational drugs. This study is not yet recruiting but aims to learn more about the effects and safety of this natural supplement in healthy adults.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults ages 18-64 years old
• • BMI 25-30 inclusive (self-reported for screening, confirmed at first study visit)
• * For purposes of blood collection and other in-person procedures:
• • o Reside within driving distance of the study center or be willing to travel to the study center
• • Willing and able to undergo three blood draws over 12 weeks
• • Willing to wash out of all internally-consumed essential oils or botanical products for at least 2 weeks prior to starting the study, and willing to maintain the washout for the duration of the study (14 weeks).
• • Willing and able to consume study product twice daily for about 12 weeks
• • Willing to track consumption of study product
• • Willing to keep diet, exercise, sleep habits, and current non-study supplement use the same throughout the study
• • Willing to limit alcohol consumption to "social drinking" (typically no more than 3 drinks per day and 7 per week) during the study
• • History of alcohol consumption limited to "social drinking" (typically no more than 3 drinks per day and 7 per week)
• • Willing to avoid recreational drugs and smoking/vaping for the duration of the study (approximately 12 weeks)
• • No metabolic disease (BMI\>30, diagnosis and treatment of hypertension, diabetes, or dyslipidemia)
• • No major diseases under treatment by doctor (Medical Reviewer's discretion)
• • No pregnancy within the last 60 days or currently breastfeeding (females)
• • No allergy to olive oil, lavender essential oil, ginger oleoresin/extract/essential oil, or OEA.
• • No regular internal consumption of lavender essential oil, ginger oleoresin or extract, or OEA within the last 1 month (regularly is defined as dosing daily for more than 2 consecutive weeks, or dosing more than 2-3 times per week for 4 consecutive weeks)
• • No evidence of medical condition, significant disease or disorder, medication, or surgery within the past 12 months that may, in the judgment of the medical provider, put the participant at risk or affect study results, procedures, or outcomes
• • No recreational drug or smoking/vaping use in the past 1 month
• • Not currently or previously participating in any other clinical trial within the last 30 calendar days
• Exclusion Criteria:
• • Failure to meet all inclusion criteria