Nctid:
NCT00000112
Payload:
{"hasResults"=>false, "derivedSection"=>{"miscInfoModule"=>{"versionHolder"=>"2024-09-05"}, "conditionBrowseModule"=>{"meshes"=>[{"id"=>"D000000052", "term"=>"Acanthosis Nigricans"}, {"id"=>"D000018149", "term"=>"Glucose Intolerance"}], "ancestors"=>[{"id"=>"D000006943", "term"=>"Hyperglycemia"}, {"id"=>"D000044882", "term"=>"Glucose Metabolism Disorders"}, {"id"=>"D000008659", "term"=>"Metabolic Diseases"}, {"id"=>"D000008548", "term"=>"Melanosis"}, {"id"=>"D000017495", "term"=>"Hyperpigmentation"}, {"id"=>"D000010859", "term"=>"Pigmentation Disorders"}, {"id"=>"D000012871", "term"=>"Skin Diseases"}], "browseLeaves"=>[{"id"=>"M12701", "name"=>"Obesity", "relevance"=>"LOW"}, {"id"=>"M7115", "name"=>"Diabetes Mellitus", "relevance"=>"LOW"}, {"id"=>"M20295", "name"=>"Glucose Intolerance", "asFound"=>"Glucose Intolerance", "relevance"=>"HIGH"}, {"id"=>"M51", "name"=>"Acanthosis Nigricans", "asFound"=>"Acanthosis Nigricans", "relevance"=>"HIGH"}, {"id"=>"M9994", "name"=>"Hyperglycemia", "relevance"=>"LOW"}, {"id"=>"M11639", "name"=>"Metabolic Diseases", "relevance"=>"LOW"}, {"id"=>"M25403", "name"=>"Glucose Metabolism Disorders", "relevance"=>"LOW"}, {"id"=>"M11531", "name"=>"Melanosis", "relevance"=>"LOW"}, {"id"=>"M19760", "name"=>"Hyperpigmentation", "relevance"=>"LOW"}, {"id"=>"M13754", "name"=>"Pigmentation Disorders", "relevance"=>"LOW"}, {"id"=>"M15674", "name"=>"Skin Diseases", "relevance"=>"LOW"}, {"id"=>"T2541", "name"=>"Glucose-galactose Malabsorption", "relevance"=>"LOW"}], "browseBranches"=>[{"name"=>"Nutritional and Metabolic Diseases", "abbrev"=>"BC18"}, {"name"=>"Symptoms and General Pathology", "abbrev"=>"BC23"}, {"name"=>"All Conditions", "abbrev"=>"All"}, {"name"=>"Gland and Hormone Related Diseases", "abbrev"=>"BC19"}, {"name"=>"Skin and Connective Tissue Diseases", "abbrev"=>"BC17"}, {"name"=>"Rare Diseases", "abbrev"=>"Rare"}]}}, "protocolSection"=>{"designModule"=>{"studyType"=>"OBSERVATIONAL", "designInfo"=>{"timePerspective"=>"OTHER", "observationalModel"=>"DEFINED_POPULATION"}}, "statusModule"=>{"overallStatus"=>"UNKNOWN", "lastKnownStatus"=>"RECRUITING", "expandedAccessInfo"=>{"hasExpandedAccess"=>false}, "statusVerifiedDate"=>"2003-12", "lastUpdateSubmitDate"=>"2005-06-23", "studyFirstSubmitDate"=>"2000-01-18", "studyFirstSubmitQcDate"=>"2000-01-18", "lastUpdatePostDateStruct"=>{"date"=>"2005-06-24", "type"=>"ESTIMATED"}, "studyFirstPostDateStruct"=>{"date"=>"2000-01-19", "type"=>"ESTIMATED"}}, "conditionsModule"=>{"conditions"=>["Obesity", "Glucose Intolerance", "Diabetes", "Acanthosis Nigricans"]}, "referencesModule"=>{"references"=>[{"pmid"=>"35235641", "type"=>"DERIVED", "citation"=>"Halloun R, Galderisi A, Caprio S, Weiss R. Lack of Evidence for a Causal Role of Hyperinsulinemia in the Progression of Obesity in Children and Adolescents: A Longitudinal Study. Diabetes Care. 2022 Jun 2;45(6):1400-1407. doi: 10.2337/dc21-2210."}, {"pmid"=>"31421157", "type"=>"DERIVED", "citation"=>"Ricke J, Klumpen HJ, Amthauer H, Bargellini I, Bartenstein P, de Toni EN, Gasbarrini A, Pech M, Peck-Radosavljevic M, Popovic P, Rosmorduc O, Schott E, Seidensticker M, Verslype C, Sangro B, Malfertheiner P. Impact of combined selective internal radiation therapy and sorafenib on survival in advanced hepatocellular carcinoma. J Hepatol. 2019 Dec;71(6):1164-1174. doi: 10.1016/j.jhep.2019.08.006. Epub 2019 Aug 14."}]}, "descriptionModule"=>{"briefSummary"=>"The prevalence of obesity in children is reaching epidemic proportions. Excess adiposity is more than just a cosmetic problem, having substantial metabolic consequences. Insulin resistance, hyperinsulinemia, impaired glucose tolerance, and frank diabetes are often seen in obese children. In this study the prevalence of impaired glucose (carbohydrate) tolerance in lean children with a family history of diabetes and obese children with acanthosis nigricans with or without a family history of diabetes mellitus will be studied."}, "eligibilityModule"=>{"sex"=>"ALL", "stdAges"=>["CHILD", "ADULT"], "maximumAge"=>"18 years", "minimumAge"=>"8 years", "healthyVolunteers"=>true, "eligibilityCriteria"=>"Inclusion Criteria:\n\n* Obesity: BM +/- 95% for age general good health"}, "identificationModule"=>{"nctId"=>"NCT00000112", "briefTitle"=>"Prevalence of Carbohydrate Intolerance in Lean and Obese Children", "organization"=>{"class"=>"NIH", "fullName"=>"National Center for Research Resources (NCRR)"}, "orgStudyIdInfo"=>{"id"=>"NCRR-M01RR06022-0029"}, "secondaryIdInfos"=>[{"id"=>"M01RR006022", "link"=>"https://reporter.nih.gov/quickSearch/M01RR006022", "type"=>"NIH"}]}, "contactsLocationsModule"=>{"locations"=>[{"zip"=>"06520-8064", "city"=>"New Haven", "state"=>"Connecticut", "status"=>"RECRUITING", "country"=>"United States", "facility"=>"Yale University School of Medicine, Pediatric Endocrinology", "geoPoint"=>{"lat"=>41.30815, "lon"=>-72.92816}}], "centralContacts"=>[{"name"=>"Sonia Caprio, M.D.", "role"=>"CONTACT", "email"=>"sonia.caprio@yale.edu", "phone"=>"1-203-764-5692"}]}, "sponsorCollaboratorsModule"=>{"leadSponsor"=>{"name"=>"National Center for Research Resources (NCRR)", "class"=>"NIH"}}}}