Nctid:
NCT00000112
Payload:
{"FullStudy"=>{"Rank"=>475479, "Study"=>{"DerivedSection"=>{"MiscInfoModule"=>{"VersionHolder"=>"December 08, 2023"}, "ConditionBrowseModule"=>{"ConditionMeshList"=>{"ConditionMesh"=>[{"ConditionMeshId"=>"D000000052", "ConditionMeshTerm"=>"Acanthosis Nigricans"}, {"ConditionMeshId"=>"D000018149", "ConditionMeshTerm"=>"Glucose Intolerance"}]}, "ConditionAncestorList"=>{"ConditionAncestor"=>[{"ConditionAncestorId"=>"D000006943", "ConditionAncestorTerm"=>"Hyperglycemia"}, {"ConditionAncestorId"=>"D000044882", "ConditionAncestorTerm"=>"Glucose Metabolism Disorders"}, {"ConditionAncestorId"=>"D000008659", "ConditionAncestorTerm"=>"Metabolic Diseases"}, {"ConditionAncestorId"=>"D000008548", "ConditionAncestorTerm"=>"Melanosis"}, {"ConditionAncestorId"=>"D000017495", "ConditionAncestorTerm"=>"Hyperpigmentation"}, {"ConditionAncestorId"=>"D000010859", "ConditionAncestorTerm"=>"Pigmentation Disorders"}, {"ConditionAncestorId"=>"D000012871", "ConditionAncestorTerm"=>"Skin Diseases"}]}, "ConditionBrowseLeafList"=>{"ConditionBrowseLeaf"=>[{"ConditionBrowseLeafId"=>"M6805", "ConditionBrowseLeafName"=>"Diabetes Mellitus", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M12391", "ConditionBrowseLeafName"=>"Obesity", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M19985", "ConditionBrowseLeafName"=>"Glucose Intolerance", "ConditionBrowseLeafAsFound"=>"Glucose Intolerance", "ConditionBrowseLeafRelevance"=>"high"}, {"ConditionBrowseLeafId"=>"M51", "ConditionBrowseLeafName"=>"Acanthosis Nigricans", "ConditionBrowseLeafAsFound"=>"Acanthosis Nigricans", "ConditionBrowseLeafRelevance"=>"high"}, {"ConditionBrowseLeafId"=>"M9684", "ConditionBrowseLeafName"=>"Hyperglycemia", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M11329", "ConditionBrowseLeafName"=>"Metabolic Diseases", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M25093", "ConditionBrowseLeafName"=>"Glucose Metabolism Disorders", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M11221", "ConditionBrowseLeafName"=>"Melanosis", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M19450", "ConditionBrowseLeafName"=>"Hyperpigmentation", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M13444", "ConditionBrowseLeafName"=>"Pigmentation Disorders", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M15364", "ConditionBrowseLeafName"=>"Skin Diseases", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"T2541", "ConditionBrowseLeafName"=>"Glucose-galactose Malabsorption", "ConditionBrowseLeafRelevance"=>"low"}]}, "ConditionBrowseBranchList"=>{"ConditionBrowseBranch"=>[{"ConditionBrowseBranchName"=>"Nutritional and Metabolic Diseases", "ConditionBrowseBranchAbbrev"=>"BC18"}, {"ConditionBrowseBranchName"=>"Gland and Hormone Related Diseases", "ConditionBrowseBranchAbbrev"=>"BC19"}, {"ConditionBrowseBranchName"=>"All Conditions", "ConditionBrowseBranchAbbrev"=>"All"}, {"ConditionBrowseBranchName"=>"Symptoms and General Pathology", "ConditionBrowseBranchAbbrev"=>"BC23"}, {"ConditionBrowseBranchName"=>"Skin and Connective Tissue Diseases", "ConditionBrowseBranchAbbrev"=>"BC17"}, {"ConditionBrowseBranchName"=>"Rare Diseases", "ConditionBrowseBranchAbbrev"=>"Rare"}]}}}, "ProtocolSection"=>{"DesignModule"=>{"StudyType"=>"Observational", "DesignInfo"=>{"DesignTimePerspectiveList"=>{"DesignTimePerspective"=>["Other"]}, "DesignObservationalModelList"=>{"DesignObservationalModel"=>["Defined Population"]}}}, "StatusModule"=>{"OverallStatus"=>"Unknown status", "LastKnownStatus"=>"Recruiting", "ExpandedAccessInfo"=>{"HasExpandedAccess"=>"No"}, "StatusVerifiedDate"=>"December 2003", "LastUpdateSubmitDate"=>"June 23, 2005", "StudyFirstSubmitDate"=>"January 18, 2000", "StudyFirstSubmitQCDate"=>"January 18, 2000", "LastUpdatePostDateStruct"=>{"LastUpdatePostDate"=>"June 24, 2005", "LastUpdatePostDateType"=>"Estimate"}, "StudyFirstPostDateStruct"=>{"StudyFirstPostDate"=>"January 19, 2000", "StudyFirstPostDateType"=>"Estimate"}}, "ConditionsModule"=>{"ConditionList"=>{"Condition"=>["Obesity", "Glucose Intolerance", "Diabetes", "Acanthosis Nigricans"]}}, "ReferencesModule"=>{"ReferenceList"=>{"Reference"=>[{"ReferencePMID"=>"35235641", "ReferenceType"=>"derived", "ReferenceCitation"=>"Halloun R, Galderisi A, Caprio S, Weiss R. Lack of Evidence for a Causal Role of Hyperinsulinemia in the Progression of Obesity in Children and Adolescents: A Longitudinal Study. Diabetes Care. 2022 Jun 2;45(6):1400-1407. doi: 10.2337/dc21-2210."}, {"ReferencePMID"=>"31421157", "ReferenceType"=>"derived", "ReferenceCitation"=>"Ricke J, Klumpen HJ, Amthauer H, Bargellini I, Bartenstein P, de Toni EN, Gasbarrini A, Pech M, Peck-Radosavljevic M, Popovic P, Rosmorduc O, Schott E, Seidensticker M, Verslype C, Sangro B, Malfertheiner P. Impact of combined selective internal radiation therapy and sorafenib on survival in advanced hepatocellular carcinoma. J Hepatol. 2019 Dec;71(6):1164-1174. doi: 10.1016/j.jhep.2019.08.006. Epub 2019 Aug 14."}]}}, "DescriptionModule"=>{"BriefSummary"=>"The prevalence of obesity in children is reaching epidemic proportions. Excess adiposity is more than just a cosmetic problem, having substantial metabolic consequences. Insulin resistance, hyperinsulinemia, impaired glucose tolerance, and frank diabetes are often seen in obese children. In this study the prevalence of impaired glucose (carbohydrate) tolerance in lean children with a family history of diabetes and obese children with acanthosis nigricans with or without a family history of diabetes mellitus will be studied."}, "EligibilityModule"=>{"Gender"=>"All", "MaximumAge"=>"18 years", "MinimumAge"=>"8 years", "StdAgeList"=>{"StdAge"=>["Child", "Adult"]}, "HealthyVolunteers"=>"Accepts Healthy Volunteers", "EligibilityCriteria"=>"Inclusion Criteria:\n\nObesity: BM +/- 95% for age general good health"}, "IdentificationModule"=>{"NCTId"=>"NCT00000112", "BriefTitle"=>"Prevalence of Carbohydrate Intolerance in Lean and Obese Children", "Organization"=>{"OrgClass"=>"NIH", "OrgFullName"=>"National Center for Research Resources (NCRR)"}, "OrgStudyIdInfo"=>{"OrgStudyId"=>"NCRR-M01RR06022-0029"}, "SecondaryIdInfoList"=>{"SecondaryIdInfo"=>[{"SecondaryId"=>"M01RR006022", "SecondaryIdLink"=>"https://reporter.nih.gov/quickSearch/M01RR006022", "SecondaryIdType"=>"U.S. NIH Grant/Contract"}]}}, "ContactsLocationsModule"=>{"LocationList"=>{"Location"=>[{"LocationZip"=>"06520-8064", "LocationCity"=>"New Haven", "LocationState"=>"Connecticut", "LocationStatus"=>"Recruiting", "LocationCountry"=>"United States", "LocationFacility"=>"Yale University School of Medicine, Pediatric Endocrinology"}]}, "CentralContactList"=>{"CentralContact"=>[{"CentralContactName"=>"Sonia Caprio, M.D.", "CentralContactRole"=>"Contact", "CentralContactEMail"=>"sonia.caprio@yale.edu", "CentralContactPhone"=>"1-203-764-5692"}]}}, "SponsorCollaboratorsModule"=>{"LeadSponsor"=>{"LeadSponsorName"=>"National Center for Research Resources (NCRR)", "LeadSponsorClass"=>"NIH"}}}}}}
