The Effects of Sex Hormones on Cognition and Mood in Older Adults
Launched by NATIONAL INSTITUTE ON AGING (NIA) · Oct 29, 1999
Trial Information
Current as of November 09, 2025
Terminated
Keywords
ClinConnect Summary
Double-blind, placebo-controlled, crossover study investigating the effects of estrogen replacement and testosterone replacement on cognition and mood in older adults. Women who have not had a hysterectomy will be given Prempro (estrogen with progesterone to protect the uterine lining), and hysterectomized women will be given Premarin (estrogen only).
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Women and men aged 65-90 who have not received hormone replacement for the last three months.
- Exclusion Criteria:
- • Previous head injury with loss of consciousness for more than one hour.
- • Men with a history of prostate cancer.
- • Men on testosterone replacement within the past three months.
- • Women with a history of breast or uterine cancer.
- • Women on estrogen replacement within the past three months.
About National Institute On Aging (Nia)
The National Institute on Aging (NIA) is a prominent research organization within the National Institutes of Health (NIH) dedicated to advancing our understanding of aging and age-related diseases. Through a robust portfolio of clinical trials, the NIA focuses on innovative research that aims to enhance the health and well-being of older adults. By fostering collaboration among scientists, healthcare professionals, and communities, the NIA seeks to translate research findings into practical solutions that improve the quality of life for aging populations. Their commitment to rigorous scientific inquiry and public health underscores their role as a leader in geriatric research and the pursuit of effective interventions for age-associated conditions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Baltimore, Maryland, United States
Patients applied
Trial Officials
Dr. Pauline Maki
Principal Investigator
National Institute on Aging, Gerontology Research Center
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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