Nctid:
NCT00000176
Payload:
{"hasResults"=>false, "derivedSection"=>{"miscInfoModule"=>{"versionHolder"=>"2024-12-20"}, "conditionBrowseModule"=>{"meshes"=>[{"id"=>"D000544", "term"=>"Alzheimer Disease"}, {"id"=>"D008569", "term"=>"Memory Disorders"}], "ancestors"=>[{"id"=>"D003704", "term"=>"Dementia"}, {"id"=>"D001927", "term"=>"Brain Diseases"}, {"id"=>"D002493", "term"=>"Central Nervous System Diseases"}, {"id"=>"D009422", "term"=>"Nervous System Diseases"}, {"id"=>"D024801", "term"=>"Tauopathies"}, {"id"=>"D019636", "term"=>"Neurodegenerative Diseases"}, {"id"=>"D019965", "term"=>"Neurocognitive Disorders"}, {"id"=>"D001523", "term"=>"Mental Disorders"}, {"id"=>"D019954", "term"=>"Neurobehavioral Manifestations"}, {"id"=>"D009461", "term"=>"Neurologic Manifestations"}], "browseLeaves"=>[{"id"=>"M3885", "name"=>"Alzheimer Disease", "asFound"=>"Alzheimer's Disease", "relevance"=>"HIGH"}, {"id"=>"M3985", "name"=>"Amnesia", "relevance"=>"LOW"}, {"id"=>"M11552", "name"=>"Memory Disorders", "asFound"=>"Memory Disorders", "relevance"=>"HIGH"}, {"id"=>"M6904", "name"=>"Dementia", "relevance"=>"LOW"}, {"id"=>"M5204", "name"=>"Brain Diseases", "relevance"=>"LOW"}, {"id"=>"M5742", "name"=>"Central Nervous System Diseases", "relevance"=>"LOW"}, {"id"=>"M23002", "name"=>"Tauopathies", "relevance"=>"LOW"}, {"id"=>"M21558", "name"=>"Neurodegenerative Diseases", "relevance"=>"LOW"}, {"id"=>"M21836", "name"=>"Neurocognitive Disorders", "relevance"=>"LOW"}, {"id"=>"M14473", "name"=>"Psychotic Disorders", "relevance"=>"LOW"}, {"id"=>"M4815", "name"=>"Mental Disorders", "relevance"=>"LOW"}, {"id"=>"M21826", "name"=>"Neurobehavioral Manifestations", "relevance"=>"LOW"}, {"id"=>"M12404", "name"=>"Neurologic Manifestations", "relevance"=>"LOW"}, {"id"=>"T2192", "name"=>"Familial Alzheimer Disease", "asFound"=>"Alzheimer's Disease", "relevance"=>"HIGH"}], "browseBranches"=>[{"name"=>"Nervous System Diseases", "abbrev"=>"BC10"}, {"name"=>"Behaviors and Mental Disorders", "abbrev"=>"BXM"}, {"name"=>"All Conditions", "abbrev"=>"All"}, {"name"=>"Symptoms and General Pathology", "abbrev"=>"BC23"}, {"name"=>"Rare Diseases", "abbrev"=>"Rare"}]}, "interventionBrowseModule"=>{"meshes"=>[{"id"=>"D011374", "term"=>"Progesterone"}, {"id"=>"D004967", "term"=>"Estrogens"}], "ancestors"=>[{"id"=>"D011372", "term"=>"Progestins"}, {"id"=>"D006728", "term"=>"Hormones"}, {"id"=>"D006730", "term"=>"Hormones, Hormone Substitutes, and Hormone Antagonists"}, {"id"=>"D045505", "term"=>"Physiological Effects of Drugs"}], "browseLeaves"=>[{"id"=>"M14245", "name"=>"Progesterone", "asFound"=>"Obese", "relevance"=>"HIGH"}, {"id"=>"M8116", "name"=>"Estrogens", "asFound"=>"Contain", "relevance"=>"HIGH"}, {"id"=>"M14244", "name"=>"Progestins", "relevance"=>"LOW"}, {"id"=>"M9789", "name"=>"Hormones", "relevance"=>"LOW"}, {"id"=>"M9788", "name"=>"Hormone Antagonists", "relevance"=>"LOW"}], "browseBranches"=>[{"name"=>"All Drugs and Chemicals", "abbrev"=>"All"}]}}, "protocolSection"=>{"designModule"=>{"phases"=>["PHASE3"], "studyType"=>"INTERVENTIONAL", "designInfo"=>{"allocation"=>"RANDOMIZED", "maskingInfo"=>{"masking"=>"DOUBLE"}, "primaryPurpose"=>"PREVENTION"}}, "statusModule"=>{"overallStatus"=>"COMPLETED", "expandedAccessInfo"=>{"hasExpandedAccess"=>false}, "statusVerifiedDate"=>"2010-11", "completionDateStruct"=>{"date"=>"2007-09", "type"=>"ACTUAL"}, "lastUpdateSubmitDate"=>"2010-11-03", "studyFirstSubmitDate"=>"1999-10-29", "studyFirstSubmitQcDate"=>"1999-10-29", "lastUpdatePostDateStruct"=>{"date"=>"2010-11-05", "type"=>"ESTIMATED"}, "studyFirstPostDateStruct"=>{"date"=>"1999-11-01", "type"=>"ESTIMATED"}, "primaryCompletionDateStruct"=>{"date"=>"2007-09", "type"=>"ACTUAL"}}, "conditionsModule"=>{"keywords"=>["Alzheimer's disease", "memory loss", "Estrogen"], "conditions"=>["Alzheimer Disease", "Memory Disorders"]}, "referencesModule"=>{"references"=>[{"pmid"=>"8709781", "type"=>"BACKGROUND", "citation"=>"Tang MX, Jacobs D, Stern Y, Marder K, Schofield P, Gurland B, Andrews H, Mayeux R. Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet. 1996 Aug 17;348(9025):429-32. doi: 10.1016/S0140-6736(96)03356-9."}, {"pmid"=>"9191758", "type"=>"BACKGROUND", "citation"=>"Kawas C, Resnick S, Morrison A, Brookmeyer R, Corrada M, Zonderman A, Bacal C, Lingle DD, Metter E. A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore Longitudinal Study of Aging. Neurology. 1997 Jun;48(6):1517-21. doi: 10.1212/wnl.48.6.1517. Erratum In: Neurology 1998 Aug;51(2):654."}, {"pmid"=>"9484355", "type"=>"BACKGROUND", "citation"=>"Jacobs DM, Tang MX, Stern Y, Sano M, Marder K, Bell KL, Schofield P, Dooneief G, Gurland B, Mayeux R. Cognitive function in nondemented older women who took estrogen after menopause. Neurology. 1998 Feb;50(2):368-73. doi: 10.1212/wnl.50.2.368."}, {"pmid"=>"17195882", "type"=>"RESULT", "citation"=>"Aloysi A, Van Dyk K, Sano M. Women's cognitive and affective health and neuropsychiatry. Mt Sinai J Med. 2006 Nov;73(7):967-75."}]}, "descriptionModule"=>{"briefSummary"=>"This is a three-year study to determine if estrogens can prevent memory loss and Alzheimer's disease in women with a family history of Alzheimer's disease.", "detailedDescription"=>"PREventing Postmenopausal memory loss and Alzheimer's with Replacement Estrogens (PREPARE) is a double-blind-placebo controlled trial to determine whether estrogen (or estrogen and progesterone) can delay the onset of memory loss or Alzheimer's Disease in elderly women with a family history of the disease."}, "eligibilityModule"=>{"sex"=>"FEMALE", "stdAges"=>["OLDER_ADULT"], "minimumAge"=>"65 years", "healthyVolunteers"=>true, "eligibilityCriteria"=>"Inclusion Criteria:\n\n* Healthy women 65 or older with a family history of memory problems not currently on estrogen.\n\nExclusion Criteria:\n\n* Significant neurological impairment\n* Current estrogen use\n* History of breast cancer"}, "identificationModule"=>{"nctId"=>"NCT00000176", "briefTitle"=>"Alzheimer's Disease Prevention Trial", "organization"=>{"class"=>"NIH", "fullName"=>"National Institute on Aging (NIA)"}, "officialTitle"=>"Alzheimer's Disease Prevention Trial. A Multi-center, Randomized, Double-blind Placebo Controlled Trial of Estrogens to Prevent Alzheimer's Disease and Loss of Memory in Women.", "orgStudyIdInfo"=>{"id"=>"IA0018"}, "secondaryIdInfos"=>[{"id"=>"RO 1AG15922-01"}]}, "armsInterventionsModule"=>{"interventions"=>[{"name"=>"Estrogen", "type"=>"DRUG"}, {"name"=>"Estrogen and Progesterone", "type"=>"DRUG"}]}, "contactsLocationsModule"=>{"locations"=>[{"zip"=>"35294", "city"=>"Birmingham", "state"=>"Alabama", "country"=>"United States", "facility"=>"University of Alabama", "geoPoint"=>{"lat"=>33.52066, "lon"=>-86.80249}}, {"zip"=>"29697-4540", "city"=>"Irvine", "state"=>"California", "country"=>"United States", "facility"=>"University of California, Irvine", "geoPoint"=>{"lat"=>33.66946, "lon"=>-117.82311}}, {"zip"=>"06902-1249", "city"=>"Stamford", "state"=>"Connecticut", "country"=>"United States", "facility"=>"New England Center for Headache", "geoPoint"=>{"lat"=>41.05343, "lon"=>-73.53873}}, {"zip"=>"20060", "city"=>"Washington", "state"=>"District of Columbia", "country"=>"United States", "facility"=>"Howard University", "geoPoint"=>{"lat"=>38.89511, "lon"=>-77.03637}}, {"zip"=>"33901", "city"=>"Fort Myers", "state"=>"Florida", "country"=>"United States", "facility"=>"Lee Memorial Health System", "geoPoint"=>{"lat"=>26.62168, "lon"=>-81.84059}}, {"zip"=>"32225", "city"=>"Jacksonville", "state"=>"Florida", "country"=>"United States", "facility"=>"Mayo Clinic Jacksonville", "geoPoint"=>{"lat"=>30.33218, "lon"=>-81.65565}}, {"zip"=>"33140", "city"=>"Miami Beach", "state"=>"Florida", "country"=>"United States", "facility"=>"Wein Center", "geoPoint"=>{"lat"=>25.79065, "lon"=>-80.13005}}, {"zip"=>"32514", "city"=>"Pensacola", "state"=>"Florida", "country"=>"United States", "facility"=>"West Florida Regional Medical Center", "geoPoint"=>{"lat"=>30.42131, "lon"=>-87.21691}}, {"city"=>"Pompano Beach", "state"=>"Florida", "country"=>"United States", "facility"=>"North Broward Medical Center", "geoPoint"=>{"lat"=>26.23786, "lon"=>-80.12477}}, {"zip"=>"32308", "city"=>"Tallahassee", "state"=>"Florida", "country"=>"United States", "facility"=>"Tallahassee Memorial Health Center", "geoPoint"=>{"lat"=>30.43826, "lon"=>-84.28073}}, {"zip"=>"33407", "city"=>"West Palm Beach", "state"=>"Florida", "country"=>"United States", "facility"=>"St. Mary's Medical Center", "geoPoint"=>{"lat"=>26.71534, "lon"=>-80.05337}}, {"zip"=>"21224", "city"=>"Baltimore", "state"=>"Maryland", "country"=>"United States", "facility"=>"Johns Hopkins Bayview Medical Center", "geoPoint"=>{"lat"=>39.29038, "lon"=>-76.61219}}, {"zip"=>"07450", "city"=>"Ridgewood", "state"=>"New Jersey", "country"=>"United States", "facility"=>"Neurology Group of Bergen County", "geoPoint"=>{"lat"=>40.97926, "lon"=>-74.11653}}, {"zip"=>"10032", "city"=>"New York", "state"=>"New York", "country"=>"United States", "facility"=>"Columbia University", "geoPoint"=>{"lat"=>40.71427, "lon"=>-74.00597}}, {"city"=>"New York", "state"=>"New York", "country"=>"United States", "facility"=>"Cornell Medical Center, New York Presbyterian Medical Center", "geoPoint"=>{"lat"=>40.71427, "lon"=>-74.00597}}, {"zip"=>"10573", "city"=>"Port Chester", "state"=>"New York", "country"=>"United States", "facility"=>"New York United Hospital Medical Center", "geoPoint"=>{"lat"=>41.00176, "lon"=>-73.66568}}, {"zip"=>"10605", "city"=>"White Plains", "state"=>"New York", "country"=>"United States", "facility"=>"Burke Medical Research Institute", "geoPoint"=>{"lat"=>41.03399, "lon"=>-73.76291}}, {"zip"=>"27710", "city"=>"Durham", "state"=>"North Carolina", "country"=>"United States", "facility"=>"Duke University Medical Center", "geoPoint"=>{"lat"=>35.99403, "lon"=>-78.89862}}, {"zip"=>"74104-5428", "city"=>"Tulsa", "state"=>"Oklahoma", "country"=>"United States", "facility"=>"Clinical Pharmaceutical Trials", "geoPoint"=>{"lat"=>36.15398, "lon"=>-95.99277}}, {"zip"=>"02906", "city"=>"Providence", "state"=>"Rhode Island", "country"=>"United States", "facility"=>"Butler Hospital, Rhode Island Hospital", "geoPoint"=>{"lat"=>41.82399, "lon"=>-71.41283}}, {"zip"=>"29406", "city"=>"North Charleston", "state"=>"South Carolina", "country"=>"United States", "facility"=>"Medical University of South Carolina", "geoPoint"=>{"lat"=>32.85462, "lon"=>-79.97481}}, {"zip"=>"23507-1912", "city"=>"Norfolk", "state"=>"Virginia", "country"=>"United States", "facility"=>"Eastern Virginia Medical School", "geoPoint"=>{"lat"=>36.84681, "lon"=>-76.28522}}], "overallOfficials"=>[{"name"=>"Mary Sano, PhD", "role"=>"PRINCIPAL_INVESTIGATOR", "affiliation"=>"Icahn School of Medicine at Mount Sinai"}]}, "sponsorCollaboratorsModule"=>{"leadSponsor"=>{"name"=>"National Institute on Aging (NIA)", "class"=>"NIH"}}}}
