Treatment of Panic Disorder: Long Term Strategies

Launched by NEW YORK STATE PSYCHIATRIC INSTITUTE · Nov 2, 1999

Keywords

ClinConnect Summary

To determine if maintenance CBT produces a more sustained improvement among patients with panic disorder (PD) who respond to an initial course of cognitive behavior therapy (CBT) alone. For those who do not respond sufficiently to CBT alone, to determine if the addition of pharmacotherapy is acceptable and if this improves response among those inadequate responders to CBT alone.

This multicenter study builds upon the findings of a prior study comparing imipramine, placebo, CBT, and their combination in the treatment of PD patients with no more than mild agoraphobia. That study found respon...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • - primary diagnosis of Panic disorder with or without Agoraphobia (all levels of agoraphobia are included).
• Exclusion Criteria:
• • current substance abuse or dependence,
• • current active suicidal potential;
• • any history of psychosis, bipolar disorder (I or II) or cyclothymia;
• • pending application or existing medical disability claim;
• • significant cognitive impairment,
• • current uncontrolled general medical illness requiring intervention,
• • psychotherapy directed at anxiety or panic which will not be discontinued by the first treatment visit, and daily use of 2mg of Xanax or equivalent.
• Exclusion criteria for paroxetine study:
• • hypersensitivity to Selective Serotonin Reuptake Inhibitors (SSRI),
• • pregnancy, lactation, or planned pregnancy during the course of the study,
• • contemporaneous medication that may interfere or interact with paroxetine,
• • prior treatment with therapeutic doses of paroxetine (40mg/d for 1 mo),
• • concurrent treatment with antidepressants.