Search / Trial NCT00000368

Treatment of Panic Disorder: Long Term Strategies

Launched by NEW YORK STATE PSYCHIATRIC INSTITUTE · Nov 2, 1999

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Trial Information

Current as of December 10, 2023

Completed

Keywords

Adult Cognitive Behavioral Therapy Pharmacotherapy Long Term Treatment Remission And Relapse Male Panic Disorder Paroxetine Serotonin Uptake Inhibitors Panic Disorder *Therapy Panic Disorder Drug Therapy Paroxetine *Therapeutic Use Serotonin Uptake Inhibitors *Therapeutic Use

Description

To determine if maintenance CBT produces a more sustained improvement among patients with panic disorder (PD) who respond to an initial course of cognitive behavior therapy (CBT) alone. For those who do not respond sufficiently to CBT alone, to determine if the addition of pharmacotherapy is acceptable and if this improves response among those inadequate responders to CBT alone. This multicenter study builds upon the findings of a prior study comparing imipramine, placebo, CBT, and their combination in the treatment of PD patients with no more than mild agoraphobia. That study found respon...

Gender

All

Eligibility criteria

  • Inclusion Criteria:
  • - primary diagnosis of Panic disorder with or without Agoraphobia (all levels of agoraphobia are included).
  • Exclusion Criteria:
  • current substance abuse or dependence,
  • current active suicidal potential;
  • any history of psychosis, bipolar disorder (I or II) or cyclothymia;
  • pending application or existing medical disability claim;
  • significant cognitive impairment,
  • current uncontrolled general medical illness requiring intervention,
  • psychotherapy directed at anxiety or panic which will not be discontinued by the first treatment visit, and daily use of 2mg of Xanax or equivalent.
  • Exclusion criteria for paroxetine study:
  • hypersensitivity to Selective Serotonin Reuptake Inhibitors (SSRI),
  • pregnancy, lactation, or planned pregnancy during the course of the study,
  • contemporaneous medication that may interfere or interact with paroxetine,
  • prior treatment with therapeutic doses of paroxetine (40mg/d for 1 mo),
  • concurrent treatment with antidepressants.

Attachments

readout_NCT00000368_2023-12-10.pdf

4.5 MB

NCT00000368_study_protocol.pdf

4.5 MB

About company

The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.

Contacts

JC

Jennifer Cobb

Immunology at National Institute of Allergy and Infectious Diseases (NIAID)

Locations

New Haven, Connecticut, United States

Boston, Massachusetts, United States

New York, New York, United States

Pittsburgh, Pennsylvania, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

At baseline and major assessment points plus monthly.

Reviews (48)

4.6

All reviews come from applied patients

5 stars
41
4 stars
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3 stars
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2 stars
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1 stars
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Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Michael Foster
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Dries Vincent
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

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