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Search / Trial NCT00000372

Glycine and D-Cycloserine in Schizophrenia

Launched by MASSACHUSETTS GENERAL HOSPITAL · Nov 2, 1999

Trial Information

Current as of May 11, 2025

Withdrawn

Keywords

Adult Amino Acids Cycloserine Female Glycine Human Male N Methylaspartate Placebos Schizophrenia Amino Acids Blood Cycloserine *Therapeutic Use Glycine *Therapeutic Use Schizophrenia *Drug Therapy Schizophrenia Physiopathology

ClinConnect Summary

To determine if glycine produces improvement in negative symptoms and D-cycloserine produces worsening in symptoms compared to placebo, patients will undergo a double blind study of d-cycloserine and glycine treatment added to clozapine.

Clozapine is more effective for negative symptoms of schizophrenia than conventional neuroleptics, but the neurochemical actions contributing to this superior clinical efficacy remain unclear. Recent evidence points to a role for glutamatergic dysregulation in schizophrenia, as well as important differences between conventional agents and clozapine in effe...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Diagnosis of Schizophrenia
  • Score of 27 or greater on the Scale for the Assessment of Negative Symptoms (SANS)
  • Treatment with stable dose of clozapine for at least 4 weeks
  • Between 18 and 65 years old
  • Exclusion Criteria:
  • No other antipsychotic medications in oral for for at least 3 months or in depot form for 6 months
  • Current major depressive episode
  • Current substance abuse diagnosis

About Massachusetts General Hospital

Massachusetts General Hospital (MGH) is a leading academic medical center located in Boston, Massachusetts, renowned for its commitment to advancing medical research and patient care. As a prominent teaching hospital affiliated with Harvard Medical School, MGH plays a pivotal role in clinical trials across a wide range of disciplines, including cardiology, oncology, neurology, and more. The institution is dedicated to fostering innovative research that translates into effective therapies and improved health outcomes. MGH's Clinical Trials Office provides comprehensive support to facilitate the design, implementation, and management of clinical studies, ensuring adherence to the highest ethical standards and regulatory compliance. With a focus on collaboration and patient-centered care, MGH strives to enhance medical knowledge and contribute to the future of healthcare.

Locations

Boston, Massachusetts, United States

Patients applied

0 patients applied

Trial Officials

Donald Goff, MD

Principal Investigator

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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