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Search / Trial NCT00000378

Antidepressant Treatment of Melancholia in Late Life

Launched by NEW YORK STATE PSYCHIATRIC INSTITUTE · Nov 2, 1999

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Trial Information

Current as of May 07, 2025

Completed

Keywords

Aged Antidepressive Agents, Tricyclic Depression Female Human Male Middle Age Nortriptyline Sertraline Serotonin Uptake Inhibitors Antidepressive Agents, Tricyclic *Therapeutic Use Antidepressive Agents, Tricyclic Adverse Effects Depression *Drug Therapy Nortriptyline *Therapeutic Use Nortriptyline Adverse Effects Sertraline *Therapeutic Use Sertraline Adverse Effects Serotonin Uptake Inhibitors *Therapeutic Use Serotonin Uptake Inhibitors Adverse Effects

ClinConnect Summary

To compare the efficacy and safety of a select serotonin re-uptake inhibitor (SSRI, sertraline) and a tricyclic antidepressant (TCA, nortriptyline) in outpatients over the age of 60 who meet Diagnostic and Statistical Manuel-IV criteria for unipolar major depression, excluding patients who meet criteria for psychotic or atypical subtype. To test the hypothesis that medication condition interacts with diagnostic subtype (melancholic vs non-melancholic) in determining antidepressant response. To examine the roles of symptom severity and alternative diagnostic subtyping in contributing to this...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • • -
  • Patients must have:
  • • Unipolar major depression (per Diagnostic and Statistical Manuel-IV criteria) with or without melancholia.
  • Exclusion Criteria:
  • • -
  • Patients with the following symptoms or conditions are excluded:
  • • Psychotic or atypical subtype of unipolar major depression.

About New York State Psychiatric Institute

The New York State Psychiatric Institute (NYSPI) is a leading research organization dedicated to advancing the understanding and treatment of mental health disorders. Affiliated with Columbia University, NYSPI integrates clinical research with cutting-edge scientific inquiry to develop innovative therapeutic strategies and improve patient care. With a focus on a wide range of psychiatric conditions, NYSPI conducts clinical trials that aim to translate findings from laboratory research into effective interventions, enhancing the quality of life for individuals affected by mental illness. Committed to ethical research practices and collaboration, NYSPI plays a pivotal role in shaping the future of psychiatric care through rigorous scientific exploration and community engagement.

Locations

New York, New York, United States

Patients applied

0 patients applied

Trial Officials

Steven P. Roose, MD

Principal Investigator

New York State Psychiatric Institute

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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