Search / Trial NCT00000378

Antidepressant Treatment of Melancholia in Late Life

Launched by NEW YORK STATE PSYCHIATRIC INSTITUTE · Nov 2, 1999

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Trial Information

Current as of March 05, 2024

Completed

Keywords

Aged Antidepressive Agents, Tricyclic Depression Female Human Male Middle Age Nortriptyline Sertraline Serotonin Uptake Inhibitors Antidepressive Agents, Tricyclic *Therapeutic Use Antidepressive Agents, Tricyclic Adverse Effects Depression *Drug Therapy Nortriptyline *Therapeutic Use Nortriptyline Adverse Effects Sertraline *Therapeutic Use Sertraline Adverse Effects Serotonin Uptake Inhibitors *Therapeutic Use Serotonin Uptake Inhibitors Adverse Effects

Description

To compare the efficacy and safety of a select serotonin re-uptake inhibitor (SSRI, sertraline) and a tricyclic antidepressant (TCA, nortriptyline) in outpatients over the age of 60 who meet Diagnostic and Statistical Manuel-IV criteria for unipolar major depression, excluding patients who meet criteria for psychotic or atypical subtype. To test the hypothesis that medication condition interacts with diagnostic subtype (melancholic vs non-melancholic) in determining antidepressant response. To examine the roles of symptom severity and alternative diagnostic subtyping in contributing to this...

Gender

All

Eligibility criteria

  • Inclusion Criteria:
  • -
  • Patients must have:
  • Unipolar major depression (per Diagnostic and Statistical Manuel-IV criteria) with or without melancholia.
  • Exclusion Criteria:
  • -
  • Patients with the following symptoms or conditions are excluded:
  • Psychotic or atypical subtype of unipolar major depression.

Attachments

readout_NCT00000378_2024-03-05.pdf

4.5 MB

NCT00000378_study_protocol.pdf

4.5 MB

About company

The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.

Contacts

JC

Jennifer Cobb

Immunology at National Institute of Allergy and Infectious Diseases (NIAID)

Locations

New York, New York, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

BASELINE COMPARED TO 12 WEEK MEASUREMENT

Reviews (48)

4.6

All reviews come from applied patients

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Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Michael Foster
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Dries Vincent
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

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