Search / Trial NCT00000406

Effects of Strength Training on Knee Osteoarthritis

Launched by INDIANA UNIVERSITY · Nov 3, 1999

Trial Information

Current as of December 09, 2024

Completed

Keywords

Osteoarthritis (Oa) Knee Radiographic Oa Strength Training Physical Therapy Exercise Body Composition Striated Muscle Depression Radiographic Oa With Knee Pain Radiographic Oa Without Knee Pain Knee Pain Without Radiographic Oa Normal Elderly (No Radiographic Oa, No Knee Pain)

ClinConnect Summary

Several studies have confirmed that weak leg muscles are associated with osteoarthritis (OA) of the knee. Studies of body composition in these people have also shown that, despite being weaker, people with OA have significantly greater muscle mass than those without OA, suggesting that those with OA may have the potential to greatly increase their strength. However, research has not clearly shown whether exercises designed to improve leg strength will decrease the severity of pain or slow the progression of OA based on radiographic (x-ray) analysis. To understand the effects of leg strength...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Males and females 60 to 100 years of age
  • Exclusion Criteria:
  • Knee joint replacement surgery
  • Diabetes mellitus
  • Uncontrollable hypertension
  • Neuropathies of the lower extremity
  • Poor mental cognition (i.e., inability to follow instructions)

Trial Officials

Alan Mikesky, PhD

Principal Investigator

Indiana University School of Medicine

About Indiana University

Indiana University, a leading research institution, is committed to advancing healthcare through innovative clinical trials and rigorous scientific inquiry. With a focus on improving patient outcomes, the university conducts a wide range of studies across various medical disciplines, leveraging its extensive resources and collaborative networks. Indiana University's dedication to ethical research practices and community engagement ensures that its clinical trials not only contribute to scientific knowledge but also prioritize participant safety and well-being. Through its commitment to excellence, Indiana University plays a pivotal role in shaping the future of medicine and enhancing public health.

Locations

Indianapolis, Indiana, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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