Effects of Strength Training on Knee Osteoarthritis
Launched by INDIANA UNIVERSITY · Nov 3, 1999
Trial Information
Current as of July 06, 2025
Completed
Keywords
ClinConnect Summary
Several studies have confirmed that weak leg muscles are associated with osteoarthritis (OA) of the knee. Studies of body composition in these people have also shown that, despite being weaker, people with OA have significantly greater muscle mass than those without OA, suggesting that those with OA may have the potential to greatly increase their strength. However, research has not clearly shown whether exercises designed to improve leg strength will decrease the severity of pain or slow the progression of OA based on radiographic (x-ray) analysis. To understand the effects of leg strength...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Males and females 60 to 100 years of age
- Exclusion Criteria:
- • Knee joint replacement surgery
- • Diabetes mellitus
- • Uncontrollable hypertension
- • Neuropathies of the lower extremity
- • Poor mental cognition (i.e., inability to follow instructions)
About Indiana University
Indiana University, a leading research institution, is committed to advancing healthcare through innovative clinical trials and rigorous scientific inquiry. With a focus on improving patient outcomes, the university conducts a wide range of studies across various medical disciplines, leveraging its extensive resources and collaborative networks. Indiana University's dedication to ethical research practices and community engagement ensures that its clinical trials not only contribute to scientific knowledge but also prioritize participant safety and well-being. Through its commitment to excellence, Indiana University plays a pivotal role in shaping the future of medicine and enhancing public health.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Indianapolis, Indiana, United States
Patients applied
Trial Officials
Alan Mikesky, PhD
Principal Investigator
Indiana University School of Medicine
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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