Calcium Supplements for Bone Health in Juvenile Rheumatoid Arthritis
Launched by CHILDREN'S HOSPITAL MEDICAL CENTER, CINCINNATI · Jan 18, 2000
Trial Information
Current as of May 09, 2025
Completed
Keywords
ClinConnect Summary
This is a randomized, double-blind, placebo-controlled trial of 24 months in which juvenile rheumatoid arthritis (JRA) patients will take either an oral calcium supplement of 1,000 mg elemental calcium per day or a matching placebo containing no calcium (Ca), plus one multivitamin per day. We hypothesize that patients receiving calcium supplementation will demonstrate at least a 10 percent greater increase in total body bone mineral density compared to those treated with placebo.
We will evaluate patients at Children's Hospital Medical Center (CHMC) every 6 months for 2 years. We will also...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • JRA Diagnosis by American College of Rheumatology diagnostic criteria
- • Age 6-18 years
- Exclusion Criteria:
- • Taking calcium supplements or calcium- containing antacids
- • Taken systemic corticosteroids in the prior 3 months
- • Use of oral contraceptives
- • Smoker
- • Have been or currently pregnant
- • Have another chronic illness that affects growth or bone mineralization (for example, Down's Syndrome, inflammatory bowel disease, steroid-dependent asthma)
- • Fasting random urinary calcium/creatinine ratio \> 0.2
About Children's Hospital Medical Center, Cincinnati
Children's Hospital Medical Center in Cincinnati is a leading pediatric healthcare institution dedicated to advancing child health through innovative clinical research and comprehensive patient care. Renowned for its commitment to excellence, the center conducts a wide range of clinical trials aimed at developing and evaluating new treatments and therapies for pediatric populations. With a focus on multidisciplinary collaboration and ethical research practices, Children's Hospital Medical Center strives to improve health outcomes for children while contributing to the broader scientific understanding of pediatric medicine.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Cincinnati, Ohio, United States
Patients applied
Trial Officials
Daniel J. Lovell, MD
Principal Investigator
Children's Hospital & Medical Center
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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