Behavioral/Drug Therapy for Alcohol-Nicotine Dependence (Naltrexone/Nicotine Patch)

Launched by THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER, HOUSTON · Nov 2, 1999

Keywords

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Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Meets criteria for alcohol and nicotine dependence.
• • Individuals will be outpatients with alcohol and nicotine dependence who have completed detoxification (medicated or nonmedicated) within the past 48-120 hours.
• • Smoking no less than 10 cigarettes/day and no greater than 50 cigarettes/day.
• • Motivated to quit smoking.
• • Willing and able to participate in the 12 week outpatient treatment.
• • Acceptable health.
• • Able to provide a collateral informant.
• • Willing to be followed for 6 months after treatment ends.
• • Willing and able to provide the names of three family members or friends to aid in locating participants for follow-up.
• Exclusion Criteria:
• • Current diagnosis of dependence on other substances except nicotine and alcohol.
• • Having moderately severe or severe alcohol withdrawal symptoms.
• • Recent (less than 48 hours) evidence of hazardous drinking (more than 2 drinks/day for females; 3 drinks/day for males).
• • History of opioid abuse.
• • Recent use of cocaine.
• • Not desiring to quit smoking.
• • Recent past or current pharmacotherapy involving naltrexone or transdermal nicotine systems.
• • History of psychosis.
• • Current suicidality, homicidally or psychiatric symptoms requiring other medications.
• • Presence of medical abnormalities that contraindicate naltrexone or nicotine replacement therapy.
• • Current treatment with psychotropic medications.
• • Pregnancy or nursing for female patients. Inability or unwillingness to participate in the 12-week outpatient treatment.

Trial Officials