Drug Therapy for Alcohol Dependence in Alaska Natives (Naltrexone/Sertraline)

Launched by YALE UNIVERSITY · Nov 2, 1999

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Eligibility criteria

• Inclusion Criteria:
• • Alaska Native having biological Alaska Native ancestry.
• • Meets criteria for alcohol dependence.
• • Prior to entering the study must be abstinent between 3 and 14 days and have a withdrawal assessment.
• • Stable residence to ensure that subjects can be located during the study.
• Exclusion Criteria:
• • Currently meets criteria for abuse or dependence on substances other than alcohol or nicotine.
• • Current use of disulfiram.
• • Psychotic or otherwise severely psychiatrically disabled.
• • Use of other psychotropic medications including antidepressants and anxiolytics.
• • Medical conditions that would not permit the use of sertraline or naltrexone, such as a history of unstable or severe hepatic, cardiovascular, metabolic, endocrine, gastrointestinal or kidney disease.
• • Hepatocellular disease or elevated bilirubin levels.
• • Females who are pregnant, nursing, or not using a reliable method of birth control.
• • Probation or parole requirements that might interfere with participation in the study.
• • Involvement in alcohol treatment other than provided by the study or AA.
• • Use of monoamine oxidase inhibitors in the past month.
• • Current use of Type 1C antiarrhythmics propafenone and flecainide.