Thrombolysis in Myocardial Infarction (TIMI)
Launched by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (NHLBI) · Oct 27, 1999
Trial Information
Current as of November 16, 2025
Completed
Keywords
ClinConnect Summary
BACKGROUND:
Coronary artery disease is the leading cause of death in the United States, accounting for almost 500,000 deaths each year. Studies have confirmed that myocardial infarction is related to an occlusive coronary thrombus in up to 80 percent of patients. First and second-generation thrombolytic agents (including streptokinase and rt-PA) have been successfully used to restore myocardial blood flow where thrombus has occluded an infarct-related coronary artery. However, further clinical investigation was necessary to determine the most suitable thrombolytic agent dose and method of ...
Gender
ALL
Eligibility criteria
- • Men and women under age 76. Patients had acute myocardial infarction.
About National Heart, Lung, And Blood Institute (Nhlbi)
The National Heart, Lung, and Blood Institute (NHLBI) is a leading component of the National Institutes of Health (NIH), dedicated to advancing research and clinical trials focused on cardiovascular, pulmonary, and hematologic diseases. With a mission to improve public health through innovative research, the NHLBI supports a wide range of studies aimed at understanding, preventing, and treating heart and lung conditions. By collaborating with academic institutions, healthcare providers, and patient communities, the NHLBI strives to translate scientific discoveries into effective clinical practices, ultimately enhancing the quality of life for individuals affected by these critical health issues.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Trial Officials
Joseph Babb
Bridgeport Hospital
Jeffery Borer
Weill Medical College of Cornell University
Bernard Chaitman
St. Louis University Medical Center
James Chesebro
Mayo Foundation
Richard Davison
Northwestern University
Harold Dodge
University of Washington
Frederick Feit
NYU Langone Health
Charles Francis
Yale University
Joel Gore
University of Massachusetts, Worcester
Michael Herman
New York Medical College
Morrison Hodges
University of Minnesota
Harvey Kemp
St. Luke's-Roosevelt Institute for Health Sciences
Genell Knatterud
Maryland Medical Research Institute
Costas Lambrew
MaineHealth
Philip Ludbrook
Washington University School of Medicine
Kenneth Mann
University of Vermont
John Markis
Beth Israel Hospital
John Morrison
North Shore University Hospital
Hiltrud Mueller
Montefiore Medical Center
Eric Powers
Columbia University
Robert Roberts
Baylor College of Medicine
Williams Rogers
University of Alabama at Birmingham
Allan Ross
George Washington University
Thomas Ryan
University Hospital Inc.
Marc Schweiger
Baystate Medical Center
Gerald Timmis
William Beaumont Hospitals
James Willerson
University of Texas
David Williams
Rhode Island Hospital
Barry Zaret
Yale University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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