Nctid:
NCT00000506
Payload:
{"FullStudy"=>{"Rank"=>474389, "Study"=>{"DerivedSection"=>{"MiscInfoModule"=>{"VersionHolder"=>"December 01, 2023"}, "ConditionBrowseModule"=>{"ConditionMeshList"=>{"ConditionMesh"=>[{"ConditionMeshId"=>"D000006331", "ConditionMeshTerm"=>"Heart Diseases"}, {"ConditionMeshId"=>"D000014652", "ConditionMeshTerm"=>"Vascular Diseases"}, {"ConditionMeshId"=>"D000009765", "ConditionMeshTerm"=>"Obesity"}]}, "ConditionAncestorList"=>{"ConditionAncestor"=>[{"ConditionAncestorId"=>"D000050177", "ConditionAncestorTerm"=>"Overweight"}, {"ConditionAncestorId"=>"D000044343", "ConditionAncestorTerm"=>"Overnutrition"}, {"ConditionAncestorId"=>"D000009748", "ConditionAncestorTerm"=>"Nutrition Disorders"}, {"ConditionAncestorId"=>"D000001835", "ConditionAncestorTerm"=>"Body Weight"}, {"ConditionAncestorId"=>"D000002318", "ConditionAncestorTerm"=>"Cardiovascular Diseases"}]}, "ConditionBrowseLeafList"=>{"ConditionBrowseLeaf"=>[{"ConditionBrowseLeafId"=>"M9109", "ConditionBrowseLeafName"=>"Heart Diseases", "ConditionBrowseLeafAsFound"=>"Heart Disease", "ConditionBrowseLeafRelevance"=>"high"}, {"ConditionBrowseLeafId"=>"M12391", "ConditionBrowseLeafName"=>"Obesity", "ConditionBrowseLeafAsFound"=>"Obesity", "ConditionBrowseLeafRelevance"=>"high"}, {"ConditionBrowseLeafId"=>"M17090", "ConditionBrowseLeafName"=>"Vascular Diseases", "ConditionBrowseLeafAsFound"=>"Vascular Disease", "ConditionBrowseLeafRelevance"=>"high"}, {"ConditionBrowseLeafId"=>"M25876", "ConditionBrowseLeafName"=>"Overweight", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M24997", "ConditionBrowseLeafName"=>"Overnutrition", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M12374", "ConditionBrowseLeafName"=>"Nutrition Disorders", "ConditionBrowseLeafRelevance"=>"low"}, {"ConditionBrowseLeafId"=>"M4804", "ConditionBrowseLeafName"=>"Body Weight", "ConditionBrowseLeafRelevance"=>"low"}]}, "ConditionBrowseBranchList"=>{"ConditionBrowseBranch"=>[{"ConditionBrowseBranchName"=>"Heart and Blood Diseases", "ConditionBrowseBranchAbbrev"=>"BC14"}, {"ConditionBrowseBranchName"=>"All Conditions", "ConditionBrowseBranchAbbrev"=>"All"}, {"ConditionBrowseBranchName"=>"Nutritional and Metabolic Diseases", "ConditionBrowseBranchAbbrev"=>"BC18"}, {"ConditionBrowseBranchName"=>"Symptoms and General Pathology", "ConditionBrowseBranchAbbrev"=>"BC23"}]}}, "InterventionBrowseModule"=>{"InterventionMeshList"=>{"InterventionMesh"=>[{"InterventionMeshId"=>"D000010645", "InterventionMeshTerm"=>"Phentermine"}, {"InterventionMeshId"=>"D000005277", "InterventionMeshTerm"=>"Fenfluramine"}]}, "InterventionAncestorList"=>{"InterventionAncestor"=>[{"InterventionAncestorId"=>"D000000697", "InterventionAncestorTerm"=>"Central Nervous System Stimulants"}, {"InterventionAncestorId"=>"D000045505", "InterventionAncestorTerm"=>"Physiological Effects of Drugs"}, {"InterventionAncestorId"=>"D000001067", "InterventionAncestorTerm"=>"Appetite Depressants"}, {"InterventionAncestorId"=>"D000019440", "InterventionAncestorTerm"=>"Anti-Obesity Agents"}, {"InterventionAncestorId"=>"D000013566", "InterventionAncestorTerm"=>"Sympathomimetics"}, {"InterventionAncestorId"=>"D000001337", "InterventionAncestorTerm"=>"Autonomic Agents"}, {"InterventionAncestorId"=>"D000018373", "InterventionAncestorTerm"=>"Peripheral Nervous System Agents"}, {"InterventionAncestorId"=>"D000018663", "InterventionAncestorTerm"=>"Adrenergic Agents"}, {"InterventionAncestorId"=>"D000018377", "InterventionAncestorTerm"=>"Neurotransmitter Agents"}, {"InterventionAncestorId"=>"D000045504", "InterventionAncestorTerm"=>"Molecular Mechanisms of Pharmacological Action"}, {"InterventionAncestorId"=>"D000017367", "InterventionAncestorTerm"=>"Selective Serotonin Reuptake Inhibitors"}, {"InterventionAncestorId"=>"D000014179", "InterventionAncestorTerm"=>"Neurotransmitter Uptake Inhibitors"}, {"InterventionAncestorId"=>"D000049990", "InterventionAncestorTerm"=>"Membrane Transport Modulators"}, {"InterventionAncestorId"=>"D000018490", "InterventionAncestorTerm"=>"Serotonin Agents"}]}, "InterventionBrowseLeafList"=>{"InterventionBrowseLeaf"=>[{"InterventionBrowseLeafId"=>"M8104", "InterventionBrowseLeafName"=>"Fenfluramine", "InterventionBrowseLeafAsFound"=>"Sub-cutaneous", "InterventionBrowseLeafRelevance"=>"high"}, {"InterventionBrowseLeafId"=>"M13240", "InterventionBrowseLeafName"=>"Phentermine", "InterventionBrowseLeafAsFound"=>"Functional MRI", "InterventionBrowseLeafRelevance"=>"high"}, {"InterventionBrowseLeafId"=>"M3719", "InterventionBrowseLeafName"=>"Central Nervous System Stimulants", "InterventionBrowseLeafRelevance"=>"low"}, {"InterventionBrowseLeafId"=>"M4069", "InterventionBrowseLeafName"=>"Appetite Depressants", "InterventionBrowseLeafRelevance"=>"low"}, {"InterventionBrowseLeafId"=>"M21086", "InterventionBrowseLeafName"=>"Anti-Obesity Agents", "InterventionBrowseLeafRelevance"=>"low"}, {"InterventionBrowseLeafId"=>"M16035", "InterventionBrowseLeafName"=>"Sympathomimetics", "InterventionBrowseLeafRelevance"=>"low"}, {"InterventionBrowseLeafId"=>"M20436", "InterventionBrowseLeafName"=>"Adrenergic Agents", "InterventionBrowseLeafRelevance"=>"low"}, {"InterventionBrowseLeafId"=>"M20194", "InterventionBrowseLeafName"=>"Neurotransmitter Agents", "InterventionBrowseLeafRelevance"=>"low"}, {"InterventionBrowseLeafId"=>"M15202", "InterventionBrowseLeafName"=>"Serotonin", "InterventionBrowseLeafRelevance"=>"low"}, {"InterventionBrowseLeafId"=>"M19339", "InterventionBrowseLeafName"=>"Selective Serotonin Reuptake Inhibitors", "InterventionBrowseLeafRelevance"=>"low"}]}, "InterventionBrowseBranchList"=>{"InterventionBrowseBranch"=>[{"InterventionBrowseBranchName"=>"All Drugs and Chemicals", "InterventionBrowseBranchAbbrev"=>"All"}, {"InterventionBrowseBranchName"=>"Anti-Obesity Agents", "InterventionBrowseBranchAbbrev"=>"AnObAg"}, {"InterventionBrowseBranchName"=>"Central Nervous System Stimulants", "InterventionBrowseBranchAbbrev"=>"CNSSti"}]}}}, "ProtocolSection"=>{"DesignModule"=>{"PhaseList"=>{"Phase"=>["Phase 2"]}, "StudyType"=>"Interventional", "DesignInfo"=>{"DesignAllocation"=>"Randomized", "DesignPrimaryPurpose"=>"Treatment", "DesignInterventionModel"=>"Parallel Assignment"}}, "StatusModule"=>{"OverallStatus"=>"Completed", "StartDateStruct"=>{"StartDate"=>"May 1983"}, "ExpandedAccessInfo"=>{"HasExpandedAccess"=>"No"}, "StatusVerifiedDate"=>"January 2000", "CompletionDateStruct"=>{"CompletionDate"=>"April 1988", "CompletionDateType"=>"Actual"}, "LastUpdateSubmitDate"=>"November 25, 2013", "StudyFirstSubmitDate"=>"October 27, 1999", "StudyFirstSubmitQCDate"=>"October 27, 1999", "LastUpdatePostDateStruct"=>{"LastUpdatePostDate"=>"November 26, 2013", "LastUpdatePostDateType"=>"Estimate"}, "StudyFirstPostDateStruct"=>{"StudyFirstPostDate"=>"October 28, 1999", "StudyFirstPostDateType"=>"Estimate"}}, "ConditionsModule"=>{"ConditionList"=>{"Condition"=>["Heart Diseases", "Obesity", "Vascular Diseases"]}}, "ReferencesModule"=>{"ReferenceList"=>{"Reference"=>[{"ReferencePMID"=>"1445528", "ReferenceType"=>"background", "ReferenceCitation"=>"Weintraub M. Long-term weight control: the National Heart, Lung, and Blood Institute funded multimodal intervention study. Clin Pharmacol Ther. 1992 May;51(5):581-5. doi: 10.1038/clpt.1992.68. No abstract available. Erratum In: Clin Pharmacol Ther 1992 Sep;52(3):323."}, {"ReferencePMID"=>"1587072", "ReferenceType"=>"background", "ReferenceCitation"=>"Weintraub M, Sundaresan PR, Madan M, Schuster B, Balder A, Lasagna L, Cox C. Long-term weight control study. I (weeks 0 to 34). The enhancement of behavior modification, caloric restriction, and exercise by fenfluramine plus phentermine versus placebo. Clin Pharmacol Ther. 1992 May;51(5):586-94. doi: 10.1038/clpt.1992.69."}, {"ReferencePMID"=>"1587073", "ReferenceType"=>"background", "ReferenceCitation"=>"Weintraub M, Sundaresan PR, Schuster B, Ginsberg G, Madan M, Balder A, Stein EC, Byrne L. Long-term weight control study. II (weeks 34 to 104). An open-label study of continuous fenfluramine plus phentermine versus targeted intermittent medication as adjuncts to behavior modification, caloric restriction, and exercise. Clin Pharmacol Ther. 1992 May;51(5):595-601. doi: 10.1038/clpt.1992.70."}, {"ReferencePMID"=>"1587074", "ReferenceType"=>"background", "ReferenceCitation"=>"Weintraub M, Sundaresan PR, Schuster B, Moscucci M, Stein EC. Long-term weight control study. III (weeks 104 to 156). An open-label study of dose adjustment of fenfluramine and phentermine. Clin Pharmacol Ther. 1992 May;51(5):602-7. doi: 10.1038/clpt.1992.71."}, {"ReferencePMID"=>"1587075", "ReferenceType"=>"background", "ReferenceCitation"=>"Weintraub M, Sundaresan PR, Schuster B, Averbuch M, Stein EC, Cox C, Byrne L. Long-term weight control study. IV (weeks 156 to 190). The second double-blind phase. Clin Pharmacol Ther. 1992 May;51(5):608-14. doi: 10.1038/clpt.1992.72."}, {"ReferencePMID"=>"1587076", "ReferenceType"=>"background", "ReferenceCitation"=>"Weintraub M, Sundaresan PR, Schuster B, Averbuch M, Stein EC, Byrne L. Long-term weight control study. V (weeks 190 to 210). Follow-up of participants after cessation of medication. Clin Pharmacol Ther. 1992 May;51(5):615-8. doi: 10.1038/clpt.1992.73."}, {"ReferencePMID"=>"1587077", "ReferenceType"=>"background", "ReferenceCitation"=>"Weintraub M, Sundaresan PR, Cox C. Long-term weight control study. VI. Individual participant response patterns. Clin Pharmacol Ther. 1992 May;51(5):619-33. doi: 10.1038/clpt.1992.74."}, {"ReferencePMID"=>"1587078", "ReferenceType"=>"background", "ReferenceCitation"=>"Weintraub M, Sundaresan PR, Schuster B. Long-term weight control study. VII (weeks 0 to 210). Serum lipid changes. Clin Pharmacol Ther. 1992 May;51(5):634-41. doi: 10.1038/clpt.1992.75."}, {"ReferencePMID"=>"1587079", "ReferenceType"=>"background", "ReferenceCitation"=>"Weintraub M. Long-term weight control study: conclusions. Clin Pharmacol Ther. 1992 May;51(5):642-6. doi: 10.1038/clpt.1992.76. No abstract available."}]}}, "DescriptionModule"=>{"BriefSummary"=>"To determine the long-term efficacy of the combination therapy of phentermine and fenfluramine in conjunction with diet, exercise, and behavior modification in the treatment of simple, moderate obesity.", "DetailedDescription"=>"BACKGROUND:\n\nObesity is a problem of significant public health concern both in this and other western countries. One reason is that it is a risk factor for cardiovascular disease, most notably hypertension. For example, in the Framingham study it was found that relative body weight, weight change during observation, and skin fold thickness were related to existing blood pressure levels and to the subsequent rate of development of hypertension. Additionally, for previously normotensive individuals, the risk of developing hypertension was proportional to the degree of overweight. Obesity is also a major risk factor for type II diabetes mellitus. On the other hand, some overweight individuals are physically healthy but suffer from the psychosocial consequences of their condition so that losing weight would be desirable for them as well as for individuals more at risk for physical illness.\n\nLike essential hypertension, obesity is not only a chronic condition for many individuals but it is also a heterogeneous condition with many underlying causes and interacting factors. It is generally difficult to treat because it is a chronic problem, success comes slowly, and physicians in practice generally understand the condition rather poorly and do not manage it well. Results from studies of caloric restriction, behavior modification and medication have often been disappointing both to the subjects and their physicians. In practice, dropout rates from exercise programs, as well as various dietary self-help programs have been relatively high.\n\nSimilarly, in clinical trials dropout rates have often been quite high. Compounding the problem of weight management has been a rather universal negative bias on the part of physicians to prescribing anorexiant medications. It was previously generally held that these agents were either only effective in the short term or not at all. Additionally, there has always been concern about the potential adverse effects of anorexiants as well as their potential for abuse. Physicians who used appetite suppressants often prescribed them for only four to six weeks which was inappropriate in the management of a chronic condition.\n\nIn several relatively short term clinical trials (e.g., 16 weeks), it has been shown that appetite control medications such as fenfluramine and phentermine were more effective than placebo in inducing weight loss. It has been less clear from the trials performed heretofore how effective anorectic medications were when used as an adjunct to behavior modification and diet. This aspect was addressed in the first two years of the clinical trial under consideration here.\n\nA second controversial issue concerned the duration of efficacy of anorexiant agents. Originally it was felt that tolerance developed, hence the recommendations for short courses of treatment. A few long-term double-blind studies using anorexiants have since demonstrated that they exert beneficial effects for up to 24 weeks, as evidenced by weight loss and maintenance of weight loss. This was an important finding given, as noted earlier, the chronicity of the problem of obesity.\n\nThe so-called stimulant anorexiants, like phentermine, are believed to act via central catecholamine mechanisms. Side-effects include nervousness, insomnia, increased motor activity and cardiovascular disturbances such as tachycardia and elevation of blood pressure. The latter effects led physicians to feel that their use in obese hypertensive patients was very limited. Fenfluramine, although chemically related to the stimulant anorexiants, appears to act via serotonergic mechanisms. It reportedly causes sedation, occasionally diarrhea and few cardiovascular effects.\n\nDESIGN NARRATIVE:\n\nDouble-blind, fixed sample. After a six-week single-blind placebo controlled diet and behavior modification period, participants entered a parallel-group comparison of fenfluramine plus phentermine versus placebo. In the third and fourth years of the study, patients were randomly assigned to either continuous therapy or intermittent therapy. The intermittent therapy group received the medication for three months from April through June and during the period between Thanksgiving and New Year's day.\n\nThe study completion date listed in this record was obtained from the Query/View/Report (QVR) System."}, "EligibilityModule"=>{"Gender"=>"All", "MaximumAge"=>"60 years", "MinimumAge"=>"18 years", "StdAgeList"=>{"StdAge"=>["Adult"]}, "HealthyVolunteers"=>"No", "EligibilityCriteria"=>"Men and women, ages 18 to 60. Body weight was 130 to 180 percent of ideal body weight."}, "IdentificationModule"=>{"NCTId"=>"NCT00000506", "BriefTitle"=>"Cardiovascular System in Obesity: Effect of Treatment", "Organization"=>{"OrgClass"=>"NIH", "OrgFullName"=>"National Heart, Lung, and Blood Institute (NHLBI)"}, "OrgStudyIdInfo"=>{"OrgStudyId"=>"25"}, "SecondaryIdInfoList"=>{"SecondaryIdInfo"=>[{"SecondaryId"=>"R01HL029188-04", "SecondaryIdLink"=>"https://reporter.nih.gov/quickSearch/R01HL029188-04", "SecondaryIdType"=>"U.S. NIH Grant/Contract"}]}}, "ArmsInterventionsModule"=>{"InterventionList"=>{"Intervention"=>[{"InterventionName"=>"fenfluramine", "InterventionType"=>"Drug"}, {"InterventionName"=>"phentermine", "InterventionType"=>"Drug"}]}}, "SponsorCollaboratorsModule"=>{"LeadSponsor"=>{"LeadSponsorName"=>"National Heart, Lung, and Blood Institute (NHLBI)", "LeadSponsorClass"=>"NIH"}}}}}}
