Search / Trial NCT00000588

Chelation Therapy of Iron Overload With Pyridoxal Isonicotinoyl Hydrazone

Launched by CASE WESTERN RESERVE UNIVERSITY · Oct 27, 1999

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Trial Information

Current as of March 05, 2024

Completed

Keywords

Description

BACKGROUND: Iron overload in patients with refractory anemia may be the consequence of repeated blood transfusion, of excessive absorption of dietary iron, or of a combination of both. The body lacks any effective means for the excretion of excess iron and in patients with refractory anemia, an inexorable accumulation of iron contained in transfused red cells or absorbed from the diet eventually exceeds the body's capacity for safe storage. Without treatment, widespread iron-induced damage to the liver, heart, pancreas, and other organs is followed by an early death, most often the result ...

Gender

All

Eligibility criteria

  • Inclusion Criteria:
  • Patients meeting any of the following health conditions and eligible for Chronic PIH Treatment
  • Non- transfusion-dependent patients with iron-loading anemias
  • Transfusion-dependent patients who have previously been well-chelated with chronic subcutaneous or intravenous desferrioxamine
  • Iron-loaded, transfusion-dependent patients
  • Ages: 18-75 years old
  • Exclusion Criteria:
  • People who are not eligible for chronic PIH therapy and not meet the medical conditions listed in the Inclusion criteria
  • Ages: 17 years old or younger or 76 years old or older

Attachments

readout_NCT00000588_2024-03-05.pdf

4.5 MB

NCT00000588_study_protocol.pdf

4.5 MB

About company

The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.

Contacts

JC

Jennifer Cobb

Immunology at National Institute of Allergy and Infectious Diseases (NIAID)

Locations

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Reviews (48)

4.6

All reviews come from applied patients

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Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Michael Foster
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Dries Vincent
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

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