A Phase I Study of the Safety and Pharmacokinetics of Recombinant CD4 Immunoglobulin G (rCD4-IgG) in HIV-1 Seropositive Women During the Last Trimester of Pregnancy and Their Newborns

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Aug 30, 2001

Keywords

ClinConnect Summary

An agent that can prevent HIV infection is desirable for those at risk of infection as well as in the pregnant female and newborn populations. Such an agent may help prevent the progression of the disease in infants and children in early stages of infections. In theory, rCD4-IgG has antiviral effects.

Part 1: Per the original protocol, a total of six pregnant women were enrolled in Groups A and B. Patients in Group A received rCD4-IgG at the onset of labor, and those in Group B received rCD4-IgG twice per week, beginning 1 week before the expected date of delivery. Newborns were not treate...

Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• Concurrent Medication:
• Allowed:
• • Iron, multivitamins, short courses of treatment for correctable medical problems (e.g., urinary tract infection), oral trimethoprim/sulfamethoxazole (TMP/SMX) or aerosolized pentamidine for prophylaxis of Pneumocystis carinii pneumonia (PCP), prophylactic antifungal therapy, or isoniazid (INH) therapy.
• • Acetaminophen.
• • Other supportive therapy (blood and blood products, vaginal creams, antiemetics, antidiarrheals, cough medicines).
• • Specific agents used during delivery, such as oxytocic agents or anesthetics. Participation in this protocol will not prevent a newborn from receiving any medication.
• Concurrent Treatment:
• Allowed:
• • Blood and blood product transfusions.
• • Gamma globulin as prophylaxis against infection with varicella virus and hepatitis virus, or RhoGAM in case of maternal-fetal incompatibility.
• Risk Behavior:
• Allowed:
• • Illicit drug use.
• Patients must be:
• • In their third trimester of pregnancy, or join the study with their newborn children.
• • Willing and able to sign informed consent.
• • Available for follow-up for at least 3 months.
• • The child should be available for follow-up for at least 1 year after delivery, and preferably longer.
• • Exclusion Criteria
• Co-existing Condition:
• Patients with the following conditions or symptoms are excluded:
• • Medical complications including, but not limited to, insulin dependent diabetes mellitus (IDDM), hypertensive disorders such as severe pre-eclampsia, eclampsia, chronic hypertension, cardiovascular disease including rheumatic or congenital heart disease, collagen vascular disease, endocarditis, and renal disease.
• • Hematological conditions including, but not limited to, hemoglobinopathies, coagulopathy, idiopathic thrombocytopenic purpura (ITP), and maternal-fetal blood incompatibilities with isoimmunization (e.g., Rh-negative mother with a positive indirect Coomb's test at any time during this pregnancy).
• • Neurological disease(s) including seizure disorders.
• • Bronchopulmonary diseases, such as severe asthma.
• • Evidence of fetal intolerance of the intrauterine environment.
• Concurrent Medication:
• Excluded:
• * Antiretroviral agents:
• • Suramin, ribavirin, HPA23, phosphonoformate, ansamycin, zidovudine (AZT), didanosine (ddI), or dideoxycytidine (ddC).
• • Other antiviral drugs, including acyclovir or ganciclovir.
• * Immunomodulating agents:
• • Interleukin 2, interferons, thymic hormones, or other agents.
• • Cytolytic chemotherapeutic agents.
• • Corticosteroids.
• • Immunoglobulin preparations.
• Concurrent Treatment:
• Excluded:
• • Radiation therapy.
• • Regular administration of gamma globulin.
• Patients with the following are excluded:
• • Serious medical or surgical complication of the pregnancy and/or delivery that required treatment during delivery or that might compromise the health of the mother or fetus.
• • Any HIV-related complications requiring antiretroviral therapy during the pregnancy, including encephalopathy and opportunistic infections.
• • Systemic infection requiring IV therapy in the month prior to enrollment in this study (IV treatment for pyelonephritis is permitted).
• Prior Medication:
• Excluded:
• • Recombinant CD4 immunoglobulin G (rCD4-IgG).
• Excluded within 4 weeks of study entry:
• * Antiretroviral agents:
• • Suramin, ribavirin, HPA23, phosphonoformate, ansamycin, zidovudine (AZT), didanosine (ddI), or dideoxycytidine (ddC).
• • Other antiviral drugs, including acyclovir or ganciclovir.
• * Immunomodulating agents:
• • Interleukin 2, interferons, thymic hormones, or other agents.
• • Cytolytic chemotherapeutic agents.
• • Corticosteroids.
• • Immunoglobulin preparations.
• Prior Treatment:
• Excluded within 4 weeks of study entry:
• • Radiation therapy.
• • History of poor medical compliance (at the discretion of the investigator). Current illicit drug use.