A Study to Evaluate the Use of Memantine In Combination With Anti-HIV Drugs to Treat AIDS Dementia Complex (ADC)

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Aug 30, 2001

Keywords

ClinConnect Summary

The signs and symptoms of the AIDS Dementia Complex can be alleviated by zidovudine (ZDV). However, ZDV therapy has been associated with significant toxicities, particularly bone marrow suppression. The efficacy of ZDV appears to decrease during the second and third years of therapy. It is not known whether this reflects cumulative toxicity. In addition, the efficacy of other antiretroviral agents remains uncertain. Hence, adjunctive therapy for cognitive and motor symptoms of AIDS is important.

Patients will be randomized to one of the following 2 arms:

Arm 1 receives memantine plus conc...

Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• You may be eligible for this study if you:
• • Are HIV positive.
• • Have been diagnosed with AIDS dementia complex (ADC).
• • Have an estimated IQ of at least 70 (before the onset of ADC) or the ability to read at a 6th grade level.
• • Have impaired mental skills.
• • Are age18 or older.
• • Exclusion Criteria
• You will not be eligible for this study if you:
• • Have a history of a neurologic disease unrelated to HIV infection.
• • Have a history of chronic seizures or head injuries.
• • Have a history of central nervous system infections.
• • Have certain cancers.
• • Have any psychiatric illness.
• • Have an active AIDS-defining opportunistic infection.
• • Are pregnant or breast-feeding.