Search / Trial NCT00000936

A Study To Test An Anti-Rejection Therapy After Kidney Transplantation

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Aug 30, 2001

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Trial Information

Current as of July 23, 2024

Terminated

Keywords

Description

Renal transplantation is recognized as the treatment of choice for children with chronic renal failure. However, patient and graft survival rates in young children are unacceptably low. In preliminary studies, OKT3 (a monoclonal antibody) induction therapy received post transplant has been more successful than standard immunosuppression alone in improving graft survival. This study is designed to assess the impact of induction therapy on graft survival in pediatric kidney transplant patients. Patients are assigned to OKT3 induction or no induction in a 1:1 ratio. Randomization to oral cycl...

Gender

All

Eligibility criteria

  • Inclusion Criteria
  • Children and young adults may be eligible for this study if they:
  • Are not yet 21 years of age.
  • Are receiving their first or second transplant.
  • Are not pregnant.
  • Agree to practice sexual abstinence or agree to use an effective
  • method of birth control/contraception during the study and
  • for 1 year after.
  • Exclusion Criteria
  • Children and young adults will not be eligible for this study if they:
  • Are recipients of multiple organs other than kidneys.
  • Are recipients of three or more transplants.
  • Are HIV positive.
  • Are Hepatitis B surface antigen positive.

Attachments

readout_NCT00000936_2024-07-23.pdf

4.5 MB

NCT00000936_study_protocol.pdf

4.5 MB

About company

The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.

Contacts

JC

Jennifer Cobb

Immunology at National Institute of Allergy and Infectious Diseases (NIAID)

Locations

Rockville, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

At 1 year

Reviews (48)

4.6

All reviews come from applied patients

5 stars
41
4 stars
6
3 stars
2
2 stars
0
1 stars
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Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Michael Foster
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Dries Vincent
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

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