Search / Trial NCT00000941

A Study on Possible Interactions Between Protease Inhibitors (Anti-HIV Drugs) and Drugs Which Lower the Level of Fat in Your Blood

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Aug 30, 2001

Trial Information

Current as of December 09, 2024

Completed

Keywords

Drug Interactions Hiv Protease Inhibitors Ritonavir Hiv Seronegativity Saquinavir Nelfinavir Anticholesteremic Agents

ClinConnect Summary

Potent antiretroviral therapy has become the standard of care for persons with HIV infection and AIDS. Recently, however, a number of complications have emerged with the widespread use of protease inhibitor (PI)-based regimens, including: hyperlipidemia, hypertriglyceridemia, diabetes mellitus, and lipodystrophy. Concern over the possibility of premature myocardial infarction has led health care providers and patients to consider treating these lipid metabolism disorders. Statin compounds have beneficial effects as lipid-lowering agents, and thereby reduce the risk of cardiovascular complic...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria
  • You may be eligible for this study if you:
  • Are HIV-negative.
  • Are between the ages of 18 and 60.
  • Agree to use a barrier method of birth control (e.g., a condom) during the study.
  • Exclusion Criteria
  • You will not be eligible for this study if you:
  • Have a history of a chronic illness such as high blood pressure, heart disease, arthritis, or diabetes.
  • Are pregnant or breast-feeding.
  • Are taking certain medications.

Trial Officials

Francesca Aweeka

Study Chair

Carl Fitchenbaum

Study Chair

About National Institute Of Allergy And Infectious Diseases (Niaid)

The National Institute of Allergy and Infectious Diseases (NIAID) is a key component of the National Institutes of Health (NIH) dedicated to advancing the understanding, prevention, and treatment of infectious and immune-mediated diseases. Through rigorous clinical trials, NIAID aims to foster innovative research that enhances public health and addresses global health challenges, including emerging infectious diseases and allergies. The institute collaborates with various partners, including academic institutions, industry, and international organizations, to translate scientific discoveries into effective therapies and vaccines. NIAID's commitment to high-quality clinical research is integral to improving health outcomes and informing policy decisions in the realm of infectious diseases and immunology.

Locations

Los Angeles, California, United States

Indianapolis, Indiana, United States

West Columbia, South Carolina, United States

San Francisco, California, United States

Seattle, Washington, United States

New York, New York, United States

Stanford, California, United States

Miami, Florida, United States

Honolulu, Hawaii, United States

Baltimore, Maryland, United States

New Orleans, Louisiana, United States

Minneapolis, Minnesota, United States

Denver, Colorado, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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