A Study on Possible Interactions Between Protease Inhibitors (Anti-HIV Drugs) and Drugs Which Lower the Level of Fat in Your Blood

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Aug 30, 2001

Keywords

ClinConnect Summary

Potent antiretroviral therapy has become the standard of care for persons with HIV infection and AIDS. Recently, however, a number of complications have emerged with the widespread use of protease inhibitor (PI)-based regimens, including: hyperlipidemia, hypertriglyceridemia, diabetes mellitus, and lipodystrophy. Concern over the possibility of premature myocardial infarction has led health care providers and patients to consider treating these lipid metabolism disorders. Statin compounds have beneficial effects as lipid-lowering agents, and thereby reduce the risk of cardiovascular complic...

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Eligibility criteria

• • Inclusion Criteria
• You may be eligible for this study if you:
• • Are HIV-negative.
• • Are between the ages of 18 and 60.
• • Agree to use a barrier method of birth control (e.g., a condom) during the study.
• • Exclusion Criteria
• You will not be eligible for this study if you:
• • Have a history of a chronic illness such as high blood pressure, heart disease, arthritis, or diabetes.
• • Are pregnant or breast-feeding.
• • Are taking certain medications.