Search / Trial NCT00000991

A Study of Three Drugs Plus Zidovudine in the Prevention of Infections in HIV-Infected Patients

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Aug 30, 2001

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Trial Information

Current as of June 13, 2024

Completed

Keywords

Trimethoprim Sulfamethoxazole Combination Toxoplasmosis Aids Related Opportunistic Infections Pneumonia, Pneumocystis Carinii Pentamidine Dapsone Drug Evaluation Drug Therapy, Combination Acquired Immunodeficiency Syndrome Zidovudine Sulfamethoxazole Trimethoprim

Description

Persons with HIV disease who are receiving AZT are at risk for PCP, toxoplasmosis, bacterial pneumonia, and other serious infections. It is therefore important to find drugs that can be given along with AZT to control these infections. Aerosolized pentamidine (PEN) has been shown to be useful in preventing PCP and is expected to lower the 2-year risk of PCP. Both sulfamethoxazole/trimethoprim (SMX/TMP) and dapsone probably also provide effective preventive treatment against PCP, and both may be useful in preventing toxoplasmosis and extrapulmonary pneumocystosis. All patients receive AZT. ...

Gender

All

Eligibility criteria

  • Inclusion Criteria
  • Concurrent Medication:
  • Allowed:
  • Antifolate medication required to treat an intercurrent infection.
  • Treatment of intercurrent infections or malignancies.
  • Fluconazole.
  • Itraconazole.
  • Standard or investigational therapy for pneumocystosis (PCP) or toxoplasmosis.
  • Only the forms of primary prophylaxis for PCP or toxoplasmosis assigned to the participant under the protocol. Patients who develop intolerance to all forms of prophylaxis assigned in this protocol or who develop PCP or toxoplasmosis may receive alternate or investigation forms of prophylaxis with or without zidovudine but must continue to be followed under this protocol.
  • Discouraged but allowed: AL-721.
  • Chronic acyclovir.
  • Ketoconazole.
  • Amphotericin B.
  • Corticosteroids at greater than physiologic replacement doses are strongly discouraged.
  • They should be used as briefly as possible and only for definite specific indications.
  • Patient must conform to the following:
  • Receiving or candidates for zidovudine therapy at least 500 mg/day under current labeled indications with no history of pneumocystosis (PCP) or toxoplasmosis.
  • Evidence of HIV infection documented by HIV antibody tests.
  • T4 cell count less than 200 cells/mm3 at any time prior to study entry.
  • Willing to sign informed consent.
  • Willing to be followed by a participating ACTG center for duration of the study.
  • Allowed: Concurrent enrollment in long-term follow-up studies in previously blinded trials of AZT (ACTG 016 and 019).
  • Exclusion Criteria
  • Co-existing Condition:
  • Patients with the following conditions are excluded:
  • History of documented or presumed pneumocystosis (PCP) or toxoplasmosis.
  • Active bacterial or mycobacterial infection.
  • History of type I hypersensitivity, exfoliative rash, or rash with mucosal involvement, severe bronchospasm, or other life-threatening reaction to any of the study drugs or to other sulfas, sulfones, or pentamidine.
  • History of intolerance causing dose interruption while receiving zidovudine at equal to or less than 600 mg/day or causing dose reduction to less than 500 mg/day within 4 weeks prior to entry.
  • Advanced Kaposi's sarcoma or other malignancy not specifically allowed that has been rapidly progressive during the month prior to enrollment or which may be expected to require chemotherapy within 90 days of study entry.
  • Concurrent Medication:
  • Excluded:
  • Active primary treatment for an infection or malignancy.
  • Other form of antifolate medication not specifically allowed.
  • Other antiretroviral or biologic response modifier.
  • Ganciclovir, if it causes intolerance to AZT equal to or more than 500 mg/day.
  • Foscarnet.
  • Patients with the following are excluded:
  • Symptoms and conditions defined in Exclusion Coexisting Conditions.
  • Glucose 6-phosphate dehydrogenase deficiency (GPD).
  • History of pneumocystosis (PCP) or toxoplasmosis.
  • History of type I hypersensitivity, exfoliative rash, or rash with mucosal involvement, severe bronchospasm, or other life-threatening reaction to any of the study drugs or to other sulfas, sulfones, or pentamidine.
  • History of intolerance causing dose interruption while receiving zidovudine at equal to or less than 500 mg/day with 4 weeks pior to study entry.
  • Prior Medication:
  • Excluded within 4 weeks of study entry:
  • Any other form of pneumocystosis (PCP) chemoprophylaxis.
  • Active substance abuse, including alcohol.

Attachments

readout_NCT00000991_2024-06-13.pdf

4.5 MB

NCT00000991_study_protocol.pdf

4.5 MB

About company

The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.

Contacts

JC

Jennifer Cobb

Immunology at National Institute of Allergy and Infectious Diseases (NIAID)

Locations

Los Angeles, California, United States

Oakland, California, United States

San Diego, California, United States

Miami, Florida, United States

Indianapolis, Indiana, United States

Baltimore, Maryland, United States

Boston, Massachusetts, United States

Boston, Massachusetts, United States

Boston, Massachusetts, United States

Minneapolis, Minnesota, United States

Saint Louis, Missouri, United States

Buffalo, New York, United States

Rochester, New York, United States

Chapel Hill, North Carolina, United States

Durham, North Carolina, United States

Cleveland, Ohio, United States

Columbus, Ohio, United States

Seattle, Washington, United States

Mbeya, , Tanzania

Pittsburgh, Pennsylvania, United States

Chicago, Illinois, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Reviews (48)

4.6

All reviews come from applied patients

5 stars
41
4 stars
6
3 stars
2
2 stars
0
1 stars
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Leslie Alexander
20 September 2023

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Michael Foster
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Dries Vincent
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

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